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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

American cutaneous leishmaniasis: In situ immune response of patients with recent and late lesions

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Author(s):
Gomes, A. H. S. ; Martines, R. B. ; Kanamura, C. T. ; Barbo, M. L. P. ; Iglezias, S. D. ; Lauletta Lindoso, J. A. ; Pereira-Chioccola, V. L.
Total Authors: 7
Document type: Journal article
Source: PARASITE IMMUNOLOGY; v. 39, n. 4 APR 2017.
Web of Science Citations: 6
Abstract

TNF-alpha, IFN-gamma, IL-10, IL-17, CD68 and CD57 were evaluated in biopsies of patients with American cutaneous leishmaniasis living in Sorocaba, Brazil. The analyses were performed considering the time of lesions from 23 patients with recent lesions (Group I) and 19 patients with late lesions (Group II). All patients were infected with Leishmania (Viannia) braziliensis. Immunostaining cells for CD68, CD57, TNF-alpha, IFN-gamma, IL-10 and IL-17 were performed by immunohistochemistry. Except for CD68 and IL-17, the distribution of in situ for CD57, IL-10, TNF-alpha and IFN-gamma showed that patients with recent lesions expressed higher levels than those with late lesions. The comparison of cytokine expression/group showed that IL-10 was significantly higher than IL-17 and IFN-gamma (similar data were shown in IL-17 compared with TNF-alpha), suggesting an immunological balance between inflammatory-anti-inflammatory agents. This balance was similar for two groups of patients. In conclusion, these data suggested that (i) patients from Group I had recent lesions (in the beginning of chronic phase) compared to those from Group II and (ii) the modulation of inflammatory response in patients with recent American cutaneous leishmaniasis was correlated with IL-10 expression in skin lesions preventing the development of mucosal forms. The parasite treatment also prevented the evolution of severe forms. (AU)

FAPESP's process: 11/13939-8 - Study of a group of fungal and parasitic infections aiming the improvement of techniques of characterization and immune-molecular diagnosis
Grantee:Vera Lúcia Pereira Chioccola
Support type: Regular Research Grants