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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPAR-Dependent AMPK Activation

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Author(s):
de Souza, Camila O. ; Teixeira, Alexandre A. S. ; Biondo, Luana A. ; Lima Junior, Edson A. ; Batatinha, Helena A. P. ; Rosa Neto, Jose C.
Total Authors: 6
Document type: Journal article
Source: Journal of Cellular Physiology; v. 232, n. 8, p. 2168-2177, AUG 2017.
Web of Science Citations: 16
Abstract

Background: Palmitoleic acid, since described as lipokine, increases glucose uptake by modulation of 5AMP-activated protein kinase (AMPK), as well as increasing lipolysis by activation of peroxisome proliferator-activated receptor- (PPAR), in adipose tissue. However, in liver, the effects of palmitoleic acid on glucose metabolism and the role of PPAR remain unknown. Objective: To investigate whether palmitoleic acid improved the hepatic insulin sensitivity of obese mice. Methods: C57BL6 and PPAR knockout (KO) mice were fed for 12 weeks with a standard diet (SD) or high-fat diet (HF), and in the last 2 weeks were treated with oleic or palmitoleic acid. Results: Palmitoleic acid promoted a faster uptake of glucose in the body, associated with higher insulin concentration; however, even when stimulated with insulin, palmitoleic acid did not modulate the insulin pathway (AKT, IRS). Palmitoleic acid increased the phosphorylation of AMPK, upregulated glucokinase and downregulated SREBP-1. Regarding AMPK downstream, palmitoleic acid increased the production of FGF-21 and stimulated the expression of PPAR. Palmitoleic acid treatment did not increase AMPK phosphorylation, modulate glucokinase or increase FGF-21 in liver of PPAR KO mice. Conclusions: In mice fed with a high-fat diet, palmitoleic acid supplementation stimulated the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPAR. J. Cell. Physiol. 232: 2168-2177, 2017. (c) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process: 13/04765-1 - Palmitoleic acid supplementation effects on immune-metabolics alterations induced by high fat diet on PPAR knockout mice
Grantee:Camila Oliveira de Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/01409-8 - The caracterization of antiinflammatory effect of palmitoleic acid suplemmentation in hepatic inflammation; The role of PPARs.
Grantee:José Cesar Rosa Neto
Support type: Regular Research Grants