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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial Screening of Endophytic Fungi Isolated from the Aerial Parts of Paepalanthus chiquitensis (Eriocaulaceae) Led to the Isolation of Secondary Metabolites Produced by Fusarium fujikuroi

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Author(s):
Felipe Hilário [1] ; Vanessa M. Chapla [2] ; Angela R. Araujo [3] ; Paulo T. Sano [4] ; Taís M. Bauab [5] ; Lourdes C. dos Santos [6]
Total Authors: 6
Affiliation:
[1] Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Biológicas - Brasil
[2] Universidade Estadual Paulista. Instituto de Química. Departamento de Química Orgânica - Brasil
[3] Universidade Estadual Paulista. Instituto de Química. Departamento de Química Orgânica - Brasil
[4] Universidade de São Paulo. Instituto de Biociências. Departamento de Botânica - Brasil
[5] Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Biológicas - Brasil
[6] Universidade Estadual Paulista. Instituto de Química. Departamento de Química Orgânica - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 28, n. 8, p. 1389-1395, 2017-08-00.
Abstract

The screening for antimicrobial activity of twenty five endophytic fungi isolated from the aerial parts of Paepalanthus chiquitensis (Eriocaulaceae) was assayed against the bacteria Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and Salmonella setubal, and the yeast fluconazole-resistant Candida albicans. The ethyl acetate extract produced by Fusarium fujikuroi was the most bioactive and this fungus was chosen for the chemical study, affording the isolation of an alkaloid 2-(4-butylpicolinamide) acetic acid and three known metabolites: fusaric acid, indole acetic acid and the sesterterpene terpestacin. The minimal inhibitory concentration of the extract and of fusaric acid and indole acetic acid for all the tested microorganisms had values from 125 to 1000 µg mL-1. (AU)

FAPESP's process: 13/12564-6 - Chemical study and evaluation of antimicrobial activity of endophytic fungi associated with Paepalanthus chiquitensis (Eriocaulaceae) and effects of chemical epigenetic modulators in the cultivation of Pochonia chlamydosporia
Grantee:Felipe Hilário
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
Grantee:Lourdes Campaner dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 13/25432-0 - In vitro and in vivo anti-Candida albicans and anti-Helicobacter pylori activity of extracts of Astronium sp. incorporated or not into nanostructured systems
Grantee:Taís Maria Bauab
Support Opportunities: Regular Research Grants