Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An overview about oxidation in clinical practice of skin aging

Full text
Author(s):
Silas Arandas Monteiro e Silva [1] ; Bozena Michniak-Kohn [2] ; Gislaine Ricci Leonardi [3]
Total Authors: 3
Affiliation:
[1] Universidade Federal de São Paulo. Medicine Department - Brasil
[2] University of New Jersey. Ernest Mario School of Pharmacy. Department of Pharmaceutics
[3] Universidade Estadual de Campinas. Faculty of Pharmaceutical Sciences - Brasil
Total Affiliations: 3
Document type: Journal article
Source: ANAIS BRASILEIROS DE DERMATOLOGIA; v. 92, n. 3, p. 367-374, 2017-06-00.
Abstract

Abstract Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect. (AU)

FAPESP's process: 13/01118-5 - Stability evaluation and clinical-laboratory study to verify and compare the efficacy and safety of retinoic acid at its daily use 0.05% and serial peeling 5.0%
Grantee:Gislaine Ricci Leonardi
Support Opportunities: Regular Research Grants