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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency

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Author(s):
Roscani, Meliza Goi ; Duarte, Juliana Da Cunha ; Augusto, Gustavo Nicolodi ; De Moraes Salgueiro, Thaysa Rodrigues ; Meireles, Mariana N. ; Gobbi, Juliana I. F. ; Okoshi, Katashi ; Hueb, Joao Carlos
Total Authors: 8
Document type: Journal article
Source: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH; v. 11, n. 6, p. OC09-OC11, JUN 2017.
Web of Science Citations: 0
Abstract

Introduction: The presence of symptoms, systolic dysfunction and Left Ventricle (LV) dilation are considered unfavourable prognostic markers in Aortic Valve Insufficiency (AVI). The role of diastolic dysfunction, which is considered unfavourable outcome marker in cardiac pathologies, is not well established in AVI. Aim: To evaluate if the presence of diastolic dysfunction may be associated with unfavourable prognostic markers in AVI patients. Materials and Methods: A cross-sectional prospective study was performed on 22 patients with moderate or severe AVI. They underwent clinical evaluation and transthoracic echocardiography. Associations between clinical, epidemio-logical and echocardiographic were evaluated by Student t-test for normally distributed variables or Mann-Whitney test for non-normal distribution. Comparison between proportions was performed by Chi-square test. Results: There was an association between increased LV filling pressure, assessed by E' and E/E' of Mitral Tissue Doppler, and impaired LV systolic function, respectively: R = 0.563, R-2 = 0.281; p = 0.008 and R = 0.639, R-2 = 0.378; p = 0.002. The LV indexed mass also was inversely associated with the LV ejection fraction (R = 0.62, R2 = 0.35 and p = 0.003). Conclusion: There was an association of LV diastolic dysfunction and ventricular hypertrophy with impaired left ventricle systolic function. Increased LV filling pressure and LV indexed mass should be considered in the management of AVI patients. (AU)

FAPESP's process: 15/00275-5 - Impact of combined exercise on diastolic function and inflammatory response in patients with heart failure and reduced ejection fraction
Grantee:Meliza Goi Roscani
Support Opportunities: Regular Research Grants