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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

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Author(s):
Haddad-Tovolli, Roberta ; Dragano, Nathalia R. V. ; Ramalho, Albina F. S. ; Velloso, Licio A.
Total Authors: 4
Document type: Review article
Source: FRONTIERS IN NEUROSCIENCE; v. 11, APR 21 2017.
Web of Science Citations: 26
Abstract

Under physiological conditions, the brain consumes over 20% of the whole body energy supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries and the neuronal network in order to provide an adequate control of molecules that are transported in and out of the brain. Alterations in the BBB structure and function affecting brain accessibility to nutrients and exit of toxins are found in a number of diseases, which in turn may disturb brain function and nutrient signaling. In this review we explore the major advances obtained in the understanding of the BBB development and how its structure impacts on function. Furthermore, we focus on the particularities of the barrier permeability in the hypothalamus, its role in metabolic control and the potential impact of hypothalamic BBB abnormities in metabolic related diseases. (AU)

FAPESP's process: 14/26942-5 - Evaluation of intracerebroventricular treatment effect with selective agonists of GPR120 and GPR40 receptors and in high fat diet induced-obesity mice
Grantee:Nathalia Romanelli Vicente Dragano
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/50278-0 - Anti-obesity effects of nutrients by hypothalamic FFA1 and FFA4 activation
Grantee:Licio Augusto Velloso
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/01868-2 - Translatome analysis of mouse POMC neurons and epigenetic analysis of the median eminence BBB in diet-induced obese offspring
Grantee:Roberta Haddad Tóvolli
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 15/02913-9 - Structural and molecular analysis of the hypotalamus median eminence of mice born from high fat diet fed mothers
Grantee:Roberta Haddad Tóvolli
Support type: Scholarships in Brazil - Post-Doctorate