| Full text | |
| Author(s): |
Caraballo-Rodriguez, Andres M.
;
Dorrestein, Pieter C.
;
Pupo, Monica T.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 7, JUL 14 2017. |
| Web of Science Citations: | 7 |
| Abstract | |
The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investigate metabolic exchange in the laboratory is through microbial interactions. Here, we describe the chemical study of selected endophytes isolated from the Brazilian medicinal plant Lychnophora ericoides by pairwise inter-kingdom interactions in order to correlate the impact of cocultivation to their metabolic profiles. Combining mass spectrometry tools and NMR analyses, a total of 29 compounds were identified. These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and leupeptins chemical families. Two of the identified compounds correspond to a new fungal metabolite (29) and a new actinobacterial angucycline- derivative (23). Our results revealed a substantial arsenal of small molecules induced by microbial interactions, as we begin to unravel the complexity of microbial interactions associated with endophytic systems. (AU) | |
| FAPESP's process: | 12/21803-1 - Elicitation of natural products biosynthesis by endophytic microorganisms’ interaction |
| Grantee: | Andrés Mauricio Caraballo Rodríguez |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery |
| Grantee: | Glaucius Oliva |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 08/09540-0 - New strategies in the search of natural antibiotics: symbiotic microorganisms as sources of compounds and in vivo assay based on Caenorhabditis elegans infection model |
| Grantee: | Mônica Tallarico Pupo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/01651-8 - Elicitation of natural products biosynthesis from endophytic microorganisms' interactions |
| Grantee: | Andrés Mauricio Caraballo Rodríguez |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |