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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

L-/M-cone opponency in visual evoked potentials of human cortex

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Author(s):
Salgueiro Barboni, Mirella Telles ; Nagy, Balazs Vince ; Gomes Martins, Cristiane Maria ; Oliveria Bonci, Daniela Maria ; Hauzman, Einat ; Aher, Avinash ; Tsai, Tina I. ; Kremers, Jan ; Ventura, Dora Fix
Total Authors: 9
Document type: Journal article
Source: JOURNAL OF VISION; v. 17, n. 9 AUG 2017.
Web of Science Citations: 4
Abstract

L and M cones send their signals to the cortex using two chromatic (parvocellular and blue-yellow koniocellular) and one luminance (magnocellular) pathways. These pathways contain ON and OFF subpathways that respond to excitation increments and decrements respectively. Here, we report on visually evoked potentials (VEP) recordings that reflect L-and M-cone driven increment (L-I and M-I) and decrement (LD and MD) activity. VEP recordings were performed on 12 trichromats and four dichromats (two protanopes and two deuteranopes). We found that the responses to L-I strongly resembled those to M-D, and that L-D and M-I responses were very similar. Moreover, the lack of a photoreceptor type (L or M) in the dichromats led to a dominance of the ON pathway of the remaining photoreceptor type. These results provide electrophysiological evidence that antagonistic L/M signal processing, already present in the retina and the lateral geniculate nucleus (LGN), is also observed at the visual cortex. These data are in agreement with results from human psychophysics where M-I stimuli lead to a perceived brightness decrease whereas L-I stimuli resulted in perceived brightness increases. VEP recording is a noninvasive tool that can be easily and painlessly applied. We propose that the technique may provide information in the diagnosis of color vision deficiencies. (AU)

FAPESP's process: 14/06457-5 - Scientific instrumentation in vision research studies at the Vision Laboratory of IPUSP
Grantee:Dora Selma Fix Ventura
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 14/25743-9 - Expression of opsins and melanopsins in snakes' retinas: molecular genetics and immunohistochemistry
Grantee:Einat Hauzman
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/26818-2 - Development and implementation of visual evaluation methods: clinical applications and animal models
Grantee:Dora Selma Fix Ventura
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/04538-3 - Dystrophin and the human visual system: study of the visual phenotypes of Duchenne muscular dystrophy patients
Grantee:Dora Selma Fix Ventura
Support type: Regular Research Grants
FAPESP's process: 16/22007-5 - Optimization of the visual functional ability in patients with macular diseases using visual training programs
Grantee:Mirella Telles Salgueiro Barboni
Support type: Scholarships abroad - Research