Gallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assays

Author(s)

Monteiro e Silva, Silas Arandas ; Fioramonti Calixto, Giovana Maria ; Cajado, Juliana ; Antunes de Carvalho, Patricia Caballieri ; Rodero, Camila Fernanda ; Chorilli, Marlus ; Leonardi, Gislaine Ricci

• Document type: Journal article
• Source: POLYMERS; v. 9, n. 9 SEP 2017.
• Web of Science Citations: 0

Abstract

Oxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratumcorneumwas evaluated by a non-invasivemethod. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 +/- 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress. (AU)

• FAPESP's process: 13/01565-1 - Mucoadhesive precursor systems of liquids crystals for buccal admnistration of antigelatinolytic peptide associated with photodynamic therapy in the treatment of oral cancer
• Grantee: Giovana Maria Fioramonti Calixto Balian
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/01118-5 - Stability evaluation and clinical-laboratory study to verify and compare the efficacy and safety of retinoic acid at its daily use 0.05% and serial peeling 5.0%
• Grantee: Gislaine Ricci Leonardi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/04908-1 - Antioxidant evaluation of natural phenolic compounds and application in topical formulations for iontophoresis in vitro
• Grantee: Gislaine Ricci Leonardi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/24180-0 - Liquid crystalline systems as potential strategy ofr incorporation of trans-resveratrol: development, physicochemical characterization and in vitro and in vivo biological assays
• Grantee: Marlus Chorilli
• Support Opportunities: Regular Research Grants