EASI-IMS an expedite and secure technique to screen for 25I-NBOH in blotter papers

Author(s)

de Morais, Damila Rodrigues ^[1] ; Barbosa, Ingrid Lopes ^[1] ; Cunha, Kelly Francisco ^[2] ; Tripodi, Guilherme Lucas ^[1] ; Figueiredo Angolini, Celio Fernando ^[1] ; Franco, Marcos Fernando ^{[3, 4]} ; de Aquino, Elvis Medeiros ^[4] ; Eberlin, Marcos Nogueira ^[1] ; Costa, Jose Luiz ^[5]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, BR-13083859 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil

^[4] SPTC, Tech Sci Police Superintendency, BR-05507060 Sao Paulo, SP - Brazil

^[5] Univ Estadual Campinas, Fac Pharmaceut Sci, BR-13083859 Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Mass Spectrometry; v. 52, n. 10, p. 701-706, OCT 2017.
• Web of Science Citations: 4

Abstract

The increasing number of new psychoactive substances (NPS) and their quick worldwide spreading, often only slightly modified in the form of new derivatives and analogues, have brought the need for fast, wide-ranging, and unequivocal identification methods in clinical and forensic investigations. Because it usually provides secure results, gas chromatography coupled to mass spectrometry (GC-MS) has been routinely employed as the standard technique for the detection of NPS in blotter papers. For 25I-NBOH (N-(2-hydroxybenzyl)-2-(4-iodo-2,5-dimethoxyphenyl) ethan-1-aminium), however, GC-MS analysis of an blotter paper extract leads to incorrect results. In this work, we investigated whether easy ambient sonic-spray mass spectrometry imaging (EASI-IMS), and ambient ionization MS method can be applied directly to the surface of the sample requiring therefore no extraction or sample preparations, would serve as an efficient, sensitive, and secure alternative for 25I-NBOH screening. (AU)

• FAPESP's process: 16/23157-0 - Development of a protocol for new synthetic cannabinoids and NBOMe (2-(2,5-dimethoxy)-N-(2-methoxybenzyl)ethan-1-amine) derivatives) analysis in scan mode precursor ion and neutral loss by GC-MS / MS and LC-MS / MS
• Grantee: Damila Rodrigues de Morais
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/10650-8 - Stability of medicines, drugs of abuse and pesticides in dried blood spots (DBS), and its application in forensic toxicology
• Grantee: José Luiz da Costa
• Support Opportunities: Regular Research Grants