Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Author(s)

Maschio, Bianca Hessel ^{[1, 2]} ; Gentil, Bianca Carvalho ^[2] ; Ajala Caetano, Erika Leao ^{[1, 2]} ; Rodrigues, Lucas Silva ^[2] ; Laurino, Leticia Favara ^{[1, 2]} ; Vieira Spim, Sara Rosicler ^{[1, 2]} ; Jozala, Angela Faustino ^{[2, 3]} ; dos Santos, Carolina Alves ^[1] ; Grotto, Denise ^{[1, 2, 3]} ; Gerenutti, Marli ^{[1, 2, 3]}

Affiliation

^[1] Univ Sorocaba, Dept Dev & Evaluat Bioact Subst, Post Grad Program Pharmaceut Sci, Rodovia Raposo Tavares Km 92-5, BR-18023000 Sorocaba, SP - Brazil

^[2] Univ Sorocaba, UNISO, Lab Toxicol Res Lapetox, Sorocaba, SP - Brazil

^[3] Univ Sorocaba, UNISO, Dept Technol & Environm Proc, Sorocaba, SP - Brazil

• Document type: Journal article
• Source: International Journal of Medicinal Mushrooms; v. 19, n. 11, p. 991-1000, 2017.
• Web of Science Citations: 2

Abstract

This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZ-GDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy. (AU)

• FAPESP's process: 15/24566-9 - Pre-clinical studies with Agaricus blazei, Lentinula edodes and Ganoderma lucidum, aiming to reduce the maternal and fetal damage caused by gestational diabetes.
• Grantee: Marli Gerenutti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/05765-5 - Assessment of biochemical and antioxidant parameters in rats exposed to Lentinula edodes (shiitake) and its possible use in metabolic disturbances
• Grantee: Denise Grotto
• Support Opportunities: Regular Research Grants