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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

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Author(s):
Maschio, Bianca Hessel [1, 2] ; Gentil, Bianca Carvalho [2] ; Ajala Caetano, Erika Leao [1, 2] ; Rodrigues, Lucas Silva [2] ; Laurino, Leticia Favara [1, 2] ; Vieira Spim, Sara Rosicler [1, 2] ; Jozala, Angela Faustino [2, 3] ; dos Santos, Carolina Alves [1] ; Grotto, Denise [1, 2, 3] ; Gerenutti, Marli [1, 2, 3]
Total Authors: 10
Affiliation:
[1] Univ Sorocaba, Dept Dev & Evaluat Bioact Subst, Post Grad Program Pharmaceut Sci, Rodovia Raposo Tavares Km 92-5, BR-18023000 Sorocaba, SP - Brazil
[2] Univ Sorocaba, UNISO, Lab Toxicol Res Lapetox, Sorocaba, SP - Brazil
[3] Univ Sorocaba, UNISO, Dept Technol & Environm Proc, Sorocaba, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Medicinal Mushrooms; v. 19, n. 11, p. 991-1000, 2017.
Web of Science Citations: 2
Abstract

This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZ-GDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy. (AU)

FAPESP's process: 15/24566-9 - Pre-clinical studies with Agaricus blazei, Lentinula edodes and Ganoderma lucidum, aiming to reduce the maternal and fetal damage caused by gestational diabetes
Grantee:Marli Gerenutti
Support type: Regular Research Grants
FAPESP's process: 13/05765-5 - Assessment of biochemical and antioxidant parameters in rats exposed to Lentinula edodes (shiitake) and its possible use in metabolic disturbances
Grantee:Denise Grotto
Support type: Regular Research Grants