| Full text | |
| Author(s): Show less - |
Tribuiani, Natalia
[1]
;
Tavares, Marylu Oliveira
[1]
;
Santana, Monique Neves
[1]
;
Fontana Oliveira, Isadora Caruso
[1]
;
do Amaral Filho, Jorge
[1]
;
Silva, Magali Glauzer
[1]
;
dos Santos, Marcio Galdino
[2]
;
Cogo, Jose Carlos
[3]
;
Floriano, Rafael Stuani
[4]
;
Cogo-Muller, Karina
[5]
;
Oshima-Franco, Yoko
[1, 6]
Total Authors: 11
|
| Affiliation: | [1] Univ Sorocaba, UNISO, Pharmaceut Sci & Pharm Grad Course, Postgrad Program, Sorocaba - Brazil
[2] Tocantins Fed Univ UFT, PGCiamb, Environm Sci Postgrad Program, Palmas - Brazil
[3] Univ Camilo Castelo Branco Unicastelo, Postgrad Program Biomed Engn & Bioengn, Descalvado - Brazil
[4] State Univ Campinas UNICAMP, Dept Pharmacol, Fac Med Sci, Campinas, SP - Brazil
[5] State Univ Campinas UNICA MP, Fac Pharmaceut Sci, Campinas, SP - Brazil
[6] Univ Brasil, Sao Paulo, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | NATURAL PRODUCT RESEARCH; v. 31, n. 23, p. 2783-2787, 2017. |
| Web of Science Citations: | 2 |
| Abstract | |
The ability of Terminalia fagifolia hydroalcoholic extract (Tf-HE) to neutralise the paralysis and myotoxicity induced by Bothrops jararacussu venom was assayed using mouse phrenic nerve-diaphragm (PND) preparation and two varieties of chick biventer cervicis (BC) preparations. Tf-HE 100 mu g/mL and 500 mu g/mL were tested against 40 and 200 mu g of venom/mL in PND and BC preparations, respectively, using pre-and post-venom incubation treatments. The effects of Tf-HE against the myotoxicity caused by venom were evaluated via histological analysis (PND) and creatine kinase (CK) release (BC). Tf-HE was able to reverse the venom paralysis in both preparation types. The contractures to exogenous ACh in BC preparations showed that Tf-HE may act on extrinsic, preserving those intrinsic postsynaptic receptors. There was a positive correlation between CK and morphological changes. The high non-hemolytic saponin content can explain the Tf-HE efficacy against the toxic effects of B. jararacussu venom in vertebrate neuromuscular preparations. {[}GRAPHICS] . (AU) | |
| FAPESP's process: | 12/08271-0 - IDENTIFICATION AND PHARMACODYNAMIC OF NEUROFACILITATING FRACTIONS OF Casearia sylvestris SW. AT THE NEUROMUSCULAR JUNCTION |
| Grantee: | Yoko Oshima Franco |
| Support Opportunities: | Regular Research Grants |