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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens

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de Amorim, Marcelo R. [1] ; Hilario, Felipe [2] ; Sano, Paulo T. [3] ; Bauab, Tais M. [2] ; dos Santos, Lourdes C. [1]
Total Authors: 5
[1] Univ Estadual Paulista UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Ciencias Biol, Escola Ciencias Farmaceut, BR-14800900 Araraquara, SP - Brazil
[3] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 29, n. 4, p. 766-774, APR 2018.
Web of Science Citations: 2

The chemical investigation of ethyl acetate extract from Paepalanthus planifolius capitula resulted in the identification of 1H-naphtho[2,3-c]pyran-1-one,9-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-10-hydroxy-7-methoxy-3-methyl, semi-vioxanthin 9-O-β-D-glucopyranoside, toralactone-9-O-β-D-glucopyranoside, paepalantine-9-O-β-D-glucopyranoside, semi-vioxanthin, 1H-naphtho[2,3-c]pyran-1-one,3,4-dihydro-9,10-dihydroxy-5,7-dimethoxy-3-methyl, vioxanthin and paepalantine dimer, and also the isolation and identification of a new naphthopyranone dimer named planifoliusin A. The chemical structures of two compounds were elucidated by performing spectroscopic 1D and 2D nuclear magnetic resonance (NMR) experiments and spectrometric HRMS (high-resolution mass spectrometry) analysis. Other six naphthopyranone dimers were proposed by MS fragmentation patterns. The minimum inhibitory concentration (MIC) values for vioxanthin (7.8 µg mL-1), planifoliusin A (15.6 µg mL-1) and the ethyl acetate extract (31.2 µg mL-1) showed antimicrobial activity against Staphylococcus aureus (ATCC 25923). (AU)

FAPESP's process: 13/25432-0 - In vitro and in vivo anti-Candida albicans and anti-Helicobacter pylori activity of extracts of Astronium sp. incorporated or not into nanostructured systems
Grantee:Taís Maria Bauab
Support type: Regular Research Grants
FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
Grantee:Lourdes Campaner dos Santos
Support type: Regular Research Grants
FAPESP's process: 13/12564-6 - Chemical study and evaluation of antimicrobial activity of endophytic fungi associated with Paepalanthus chiquitensis (Eriocaulaceae) and effects of chemical epigenetic modulators in the cultivation of Pochonia chlamydosporia
Grantee:Felipe Hilário
Support type: Scholarships in Brazil - Master