Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens

Author(s)

de Amorim, Marcelo R. ^[1] ; Hilario, Felipe ^[2] ; Sano, Paulo T. ^[3] ; Bauab, Tais M. ^[2] ; dos Santos, Lourdes C. ^[1]

Affiliation

^[1] Univ Estadual Paulista UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Dept Ciencias Biol, Escola Ciencias Farmaceut, BR-14800900 Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 29, n. 4, p. 766-774, APR 2018.
• Web of Science Citations: 2

Abstract

The chemical investigation of ethyl acetate extract from Paepalanthus planifolius capitula resulted in the identification of 1H-naphtho[2,3-c]pyran-1-one,9-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-10-hydroxy-7-methoxy-3-methyl, semi-vioxanthin 9-O-β-D-glucopyranoside, toralactone-9-O-β-D-glucopyranoside, paepalantine-9-O-β-D-glucopyranoside, semi-vioxanthin, 1H-naphtho[2,3-c]pyran-1-one,3,4-dihydro-9,10-dihydroxy-5,7-dimethoxy-3-methyl, vioxanthin and paepalantine dimer, and also the isolation and identification of a new naphthopyranone dimer named planifoliusin A. The chemical structures of two compounds were elucidated by performing spectroscopic 1D and 2D nuclear magnetic resonance (NMR) experiments and spectrometric HRMS (high-resolution mass spectrometry) analysis. Other six naphthopyranone dimers were proposed by MS fragmentation patterns. The minimum inhibitory concentration (MIC) values for vioxanthin (7.8 µg mL-1), planifoliusin A (15.6 µg mL-1) and the ethyl acetate extract (31.2 µg mL-1) showed antimicrobial activity against Staphylococcus aureus (ATCC 25923). (AU)

• FAPESP's process: 13/12564-6 - Chemical study and evaluation of antimicrobial activity of endophytic fungi associated with Paepalanthus chiquitensis (Eriocaulaceae) and effects of chemical epigenetic modulators in the cultivation of Pochonia chlamydosporia
• Grantee: Felipe Hilário
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
• Grantee: Lourdes Campaner dos Santos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/25432-0 - In vitro and in vivo anti-Candida albicans and anti-Helicobacter pylori activity of extracts of Astronium sp. incorporated or not into nanostructured systems
• Grantee: Taís Maria Bauab
• Support Opportunities: Regular Research Grants