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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours

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Author(s):
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Barra, C. N. [1, 2] ; Macedo, B. M. [2] ; Cadrobbi, K. G. [2] ; Pulz, L. H. [1, 2] ; Huete, G. C. [2] ; Kleeb, S. R. [3] ; Xavier, J. G. [4] ; Catao-Dias, J. L. [1] ; Nishiya, A. T. [5] ; Fukumasu, H. [2] ; Strefezzi, R. F. [2]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Dept Pathol, Fac Med Vet & Zootecnia, Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Oncol Comparada & Translac, Fac Zootecnia & Engn Alimentos, Pirassununga - Brazil
[3] Univ Metodista Sao Paulo, Sao Bernardo Do Campo - Brazil
[4] Univ Paulista, Sao Paulo - Brazil
[5] Univ Anhembi Morumbi, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: VETERINARY AND COMPARATIVE ONCOLOGY; v. 16, n. 1, p. E38-E44, MAR 2018.
Web of Science Citations: 2
Abstract

Mast cell tumours (MCTs) are the most frequent canine round cell neoplasms and show variable biological behaviours with high metastatic and recurrence rates. The disease is treated surgically and wide margins are recommended. Adjuvant chemotherapy and radiotherapy used in this disease cause DNA damage in neoplastic cells, which is aimed to induce apoptotic cell death. Resisting cell death is a hallmark of cancer, which contributes to the development and progression of tumours. The aim of this study was to investigate the expression of the proteins involved in the apoptotic intrinsic pathway and to evaluate their potential use as prognostic markers for canine cutaneous MCTs. Immunohistochemistry for BAX, BCL2, APAF1, Caspase-9, and Caspase-3 was performed in 50 canine cases of MCTs. High BAX expression was associated with higher mortality rate and shorter survival. BCL2 and APAF1 expressions offered additional prognostic information to the histopathological grading systems. The present results indicate that variations in the expression of apoptotic proteins are related to malignancy of cutaneous MCTs in dogs. (AU)

FAPESP's process: 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants
FAPESP's process: 16/03862-1 - Characterization of cancer associated fibroblasts and its influence on canine neoplasms
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants