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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adsorptive stripping voltammetry for simultaneous determination of hydrochlorothiazide and triamterene in hemodialysis samples using a multi-walled carbon nanotube-modified glassy carbon electrode

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Author(s):
Hudari, Felipe Fantinato [1] ; Souza, Joao Carlos [1] ; Boldrin Zanoni, Maria Valnice [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Paulista UNESP, Inst Quim, Araraquara - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Talanta; v. 179, p. 652-657, MAR 1 2018.
Web of Science Citations: 6
Abstract

Hemodialysis is the most commonly used method for the treatment of chronic kidney disease. In this procedure, some patients use diuretics to control weight gain and blood pressure. In this work, a voltammetric sensor based on a glassy carbon electrode modified with carbon nanotubes (GCE/MWCNT) is described for the simultaneous determination of the diuretics hydrochlorothiazide (HCT) and triamterene (TRT). The oxidation of the diuretics on the GCE/MWCNT surface was observed at 1.01 and 1.17 V for HCT and TRT, respectively, allowing simultaneous determination, which was not possible with the unmodified glassy carbon electrode. The GCE/MWCNT electrode provided 6-fold and 10-fold gains in anode peak intensity for HCT and TRT, respectively, compared to the unmodified electrode. After optimization of the conditions (pH, accumulation time, and accumulation potential), analytical curves were constructed for the analytes in the range from 1.0 x 10(-7) to 2.0 x 10(-5) mol L-1. The detection limits for HCT and TRT were 2.8 x 10(-8) and 2.9 x 10(-8) mol L-1, respectively. A high performance liquid chromatography method with diode array detection was also developed for the determination of HCT and TRT in hemodialysis samples, for comparison with the electroanalytical method. (AU)

FAPESP's process: 15/18109-4 - Contribution of Nanostructured Materials in Electroanalysis of pharmaceuticals and dyes, in the oxidation and reduction photoeletrocatalytic process of Inorganic and Organic Pollutants and Water Disinfection.
Grantee:Maria Valnice Boldrin
Support Opportunities: Regular Research Grants
FAPESP's process: 15/12998-1 - Chromatographic and electroanalytical methods applied in determination of p-toluenediamine and p-aminophenol in oxidative medium used in permanent hair dye.
Grantee:João Carlos de Souza
Support Opportunities: Scholarships in Brazil - Doctorate