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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study

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Author(s):
Norde, Marina Maintinguer [1] ; Oki, Erica [1] ; Ferreira Carioca, Antonio Augusto [1] ; Teixeira Damasceno, Nagila Raquel [1] ; Fisberg, Regina Mara [1] ; Lobo Marchioni, Dirce Maria [1] ; Rogero, Marcelo Macedo [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Dr Arnaldo Ave 715, BR-01246904 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Clinical Nutrition; v. 37, n. 2, p. 659-666, APR 2018.
Web of Science Citations: 5
Abstract

Background \& aims: Metabolic syndrome (MetS) is a cluster of interrelated risk factors for type 2 diabetes mellitus, and cardiovascular disease, with underlying inflammatory pathophysiology. Genetic variations and diet are well-known risk factor for MetS, but the interaction between these two factors is less explored. The aim of the study was to evaluate the influence of interaction between SNP of inflammatory genes (encoding interleukin (IL)-6, IL-beta and IL-10) and plasma fatty acids on the odds of MetS, in a population-based cross-sectional study. Methods: Among participants of the Health Survey - Sao Paulo, 301 adults (19-59 y) from whom a blood sample was collected were included. Individuals with and without MetS were compared according to their plasma inflammatory biomarkers, fatty acid profile, and genotype frequency of the IL1B (rs16944, rs1143623, rs1143627, rs1143634 and rs1143643), IL6 (rs1800795, rs1800796 and rs1800797) and IL10 (rs1554286, rs1800871, rs1800872, rs1800890 and rs3024490) genes SNP. The influence of gene fatty acids interaction on MetS risk was investigated. Results: IL6 gene SNP rs1800795 G allele was associated with higher odds for MetS (OR = 1.88; p = 0.017). Gene fatty acid interaction was found between the IL1B gene SNP rs116944 and stearic acid (p inter = 0.043), and between rs1143634 and EPA (p inter = 0.017). For the IL10 gene SNP rs1800896, an interaction was found for arachidonic acid (p inter = 0.007) and estimated D5D activity (p inter = 0.019). Conclusion: The 1L6 gene SNP rs1800795 G allele is associated with increased odds for MetS. Plasma fatty acid profile interacts with the IL1B and IL10 gene variants to modulate the odds for MetS. This and other interactions of risk factors can account for the unexplained heritability of MetS, and their elucidation can lead to new strategies for genome-customized prevention of MetS. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)

FAPESP's process: 14/16347-2 - Metabolic signature on migrants and their relationship to patterns of consumption and metabolic syndrome: an epidemiological approach to elucidate the effects of diet
Grantee:Antonio Augusto Ferreira Carioca
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/20401-7 - Association between SNP related to adiponectin, C-reactive protein, Toll Like Receptor 4, TNF-alfa, IL-1 beta, IL-6 and IL-10 genes and lipids intake and their effects on plasma inflammatory biomarkers levels in population-based study
Grantee:Marcelo Macedo Rogero
Support Opportunities: Regular Research Grants
FAPESP's process: 13/01741-4 - Association between single nucleotide polymorphism in genes of CRP, TNF-alfa and IL-10 and plasma fatty acids and their effect to a systemic inflammatory patter at a population-based study - ISA-Capital
Grantee:Érica Oki
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/01740-8 - Association between single nucleotide polymorphism related to adiponectin, Toll like receptor 4, IL-1² and IL-6 genes and fatty acids intake and their effects on systemic inflammatory pattern in a population based study - ISA capital.
Grantee:Marina Maintinguer Norde
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
Grantee:Regina Mara Fisberg
Support Opportunities: Regular Research Grants