| Full text | |
| Author(s): Show less - |
Jonco Aquino-Junior, Jefferson Comin
[1]
;
MacKenzie, BreAnne
[2]
;
Almeida-Oliveira, Ana Roberta
[1]
;
Martins, Ana Carolina
;
Oliveira-Junior, Manoel Carneiro
[1, 2]
;
Britto, Aurilea Aparecida
[1]
;
Arantes-Costa, Fernanda Magalhaes
[3, 4]
;
Damaceno-Rodrigues, Nilsa Regina
[5]
;
Caldini, Elia Garcia
[5]
;
Ligeiro de Oliveira, Ana Paula
[1, 2]
;
Guadagnini, Dioze
;
Leiria, Luiz Osorio
;
Ricardo, Djalma Rabelo
[6]
;
Abdalla Saad, Mario Jose
;
Vieira, Rodolfo Paula
[2, 6, 7]
Total Authors: 15
|
| Affiliation: | [1] Nove de Julho Univ, Rua Vergueiro 235-249, BR-01504001 Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, Ave Doutor Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[4] State Univ Campinas UNICAMP, Dept Internal Med, Rua Tessalia Vieira de Camargo 126, BR-13083887 Campinas, SP - Brazil
[5] Univ Sao Paulo, Sch Med, Lab Cellular Biol LIM 59, Ave Doutor Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[6] Sch Med Sci Sao Jose dos Campos Humanitas, Ave Brigadeiro Faria Lima 811, BR-12227000 Sao Jose Dos Campos, SP - Brazil
[7] Univ Brasil, Rua Carolina Fonseca, 584 Itaquera, BR-08230030 Sao Paulo, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | CYTOKINE; v. 104, p. 46-52, APR 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Purpose: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyperresponsiveness (AHR), remodeling and inflammation.\& para;\& para;Methods: Sixty C57B1/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15). A classical model of diet-induced obesity (DIO) over 12 weeks was used. AE was performed 60 min/day, 5 days/week for 5 weeks. Airway hyperresponsiveness (AHR), lung inflammation and remodeling, adipokines and cytokines in bronchoalveolar lavage (BAL) was determined.\& para;\& para;Results: A high fat diet over 18 weeks significantly increased body weight (p < .0001). Five weeks of AE significantly reduced both AHR and pulmonary inflammation. AHR in obese mice that exercised was reduced at the basal level (p < .05), vehicle (PBS) (p < .05), 6.25 MCh mg/mL (p < .05), 12.5 MCh mg/mL (p < .01), 25 MCh mg/mL (p < .01) and 50 MCh mg/mL (p < .05). Collagen (p < .001) and elastic (p < .001) fiber deposition in airway wall and also smooth muscle thickness (p < .001) were reduced. The number of neutrophils (p < .001), macrophages (p < .001) and lymphocytes (p < .01) were reduced in the peribronchial space as well as in the BAL: lymphocytes (p < .01), macrophages (p < .01), neutrophils (p < .001). AE reduced obesity markers leptin (p < .001), IGF-1 (p < .01) and VEGF (p < .001), while increased adiponectin (p < .01) in BAL. AE also reduced pro-inflammatory cytokines in the SAL: IL-1 beta (p < .001), IL-12p40 (p < .001), IL-13 (p < .01), IL-17 (p < .001, IL-23 (p < .05) and TNF-alpha (p < .05), and increased antiinflammatory cytokine IL-10 (p < .05).\& para;\& para;Conclusions: Aerobic exercise reduces high fat diet-induced obese lung phenotype (AHR, pulmonary remodeling and inflammation), involving anti-inflammatory cytokine IL-10 and adiponectin. (AU) | |
| FAPESP's process: | 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite |
| Grantee: | Manoel Carneiro de Oliveira Junior |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/07500-1 - Role of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic exercise in an experimental model of asthma |
| Grantee: | Ana Roberta Almeida Comin |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |