Exercise Performed Concomitantly with Particulate Matter Exposure Inhibits Lung Injury

Author(s):Show less -

Silva-Renno, Adriano ^{[1, 2]} ; Baldivia, Guilherme Crisitanini ^{[1, 2]} ; Oliveira-Junior, Manoel C. ^[3] ; Rodrigues Brandao-Rangel, Maysa Alves ^{[1, 2]} ; El-Mafarjeh, Elias ^{[1, 2]} ; Dolhnikoff, Marisa ^[4] ; Mauad, Thais ^[4] ; Britto, Jose Mara ^[5] ; Nascimento Saldiva, Paulo Hilario ^[6] ; Franco Oliveira, Luis Vicente ^{[1, 2]} ; Ligeiro-Oliveira, Ana P. ^[3] ; Graudenz, Gustavo Silveira ^{[1, 2]} ; Vieira, Rodolfo Paula ^{[7, 8]}

Affiliation

^[1] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Paulo - Brazil

^[2] Nove Julho Univ UNINOVE, Lab Pulm & Exercise Immunol LABPEI, Sao Paulo - Brazil

^[3] Nove Julho Univ UNINOVE, MSc & PhD Program Rehabil Sci & MSc Med, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Pathol, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Med, Pathol LIM 5, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Pathol, Sao Paulo - Brazil

^[7] Sch Med Sci Sao dos Jose Campos Humanitas, Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos - Brazil

^[8] Univ Brasil, Lab Pulm & Exercise Immunol LABPEI, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 39, n. 2, p. 133-140, FEB 2018.
• Web of Science Citations: 2

Abstract

Air pollution is a growing problem worldwide, inducing and exacerbating several diseases. Among the several components of air pollutants, particulate matter (PM), especially thick (10-2.5 mu m; PM 10) and thin (2.5 mu m; PM 2.5), are breathable particles that easily can be deposited within the lungs, resulting in pulmonary and systemic inflammation. Although physical activity is strongly recommended, its effects when practiced in polluted environments are questionable. Therefore, the present study evaluated the pulmonary and systemic response of concomitant treadmill training with PM 2.5 and PM 10 exposure. Treadmill training inhibited PM 2.5- and PM 10-induced accumulation of total leukocytes (p<0.001), neutrophils (p<0.001), macrophages (p<0.001) and lymphocytes (p<0.001) in bronchoalveolar lavage (BAL), as well as the BAL levels of IL-1beta (p<0.001), CXCL1/KC (p<0.001) and TNF-alpha (p<0.001), whereas it increased IL-10 levels (p<0.05). Similar effects were observed on accumulation of polymorphonuclear (p<0.01) and mononuclear (p<0.01) cells in the lung parenchyma and in the peribronchial space. Treadmill training also inhibited PM 2.5- and PM 10-induced systemic inflammation, as observed in the number of total leukocytes (p<0.001) and in the plasma levels of IL-1beta (p<0.001), CXCL1/KC (p<0.001) and TNF-alpha (p<0.001), whereas it increased IL-10 levels (p<0.001). Treadmill training inhibits lung and systemic inflammation induced by particulate matter. (AU)

• FAPESP's process: 15/18821-6 - Effects of aerobic exercise training in pulmonary changes induced by different products of air pollution
• Grantee: Guilherme Cristianini Baldivia
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
• Grantee: Rodolfo de Paula Vieira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite
• Grantee: Manoel Carneiro de Oliveira Junior
• Support Opportunities: Scholarships in Brazil - Doctorate