Pt(II) and Pd(II) complexes with ibuprofen hydrazide: Characterization, theoretical calculations, antibacterial and antitumor assays and studies of interaction with CT-DNA

Author(s)

Manzano, Carlos M. ^[1] ; Bergamini, Fernando R. G. ^[1] ; Lustri, Wilton R. ^[2] ; Ruiz, Ana Lucia T. G. ^{[3, 4]} ; de Oliveira, Ellen C. S. ^[3] ; Ribeiro, Marcos A. ^[5] ; Formiga, Andre L. B. ^[1] ; Corbi, Pedro P. ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Inst Chem, Inorgan Chem Dept, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Araraquara UNIARA, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil

^[3] Univ Campinas UNICAMP, Biol & Agr Pluridisciplinary Res Ctr CPQBA, Chem, BR-13148218 Pautinia, SP - Brazil

^[4] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil

^[5] Fed Univ Espirito Santo UFES, Chem Dept, Vitoria 29075910, ES - Spain

• Document type: Journal article
• Source: Journal of Molecular Structure; v. 1154, p. 469-479, FEB 15 2018.
• Web of Science Citations: 6

Abstract

Palladium(II) and platinum(II) complexes with a hydrazide derivative of ibuprofen (named HIB) were synthesized and characterized by chemical and spectroscopic methods. Elemental and thermogravimetric analyses, as well as ESI-QTOF-MS studies for both complexes, confirmed a 1:2:2 metal/HIB/C- molar ratio. The crystal structure of the palladium(II) complex was solved by single crystal X-ray diffractometric analysis, which permitted identifying the coordination formula {[}PdCl2(HIB)(2)]. Crystallographic studies also indicate coordination of HIB to the metal by the NH2 group. Nuclear magnetic resonance and infrared spectroscopies reinforced the coordination observed in the crystal structure and suggested that the platinum(II) complex presents similar coordination modes and structure when compared with the Pd(II) complex. The complexes had their structures optimized with the aid of DFT methods. In vitro antiproliferative assays showed that the {[}PdCl2(HIB)(2)] complex is active over ovarian cancer cell line OVCAR-03, while biophysical studies indicated its capacity to interact with CT-DNA. The complexes were inactive over Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacterial strains. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 15/25114-4 - Synthesis of New Ag(I), Cu(II), Pd(II) and Pt(II) complexes based on sulfonamides and derivatives: antibacterial activities and application prospects on skin critically colonized wounds.
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/22127-2 - Development of novel materials strategic for integrated analytical devices
• Grantee: Lauro Tatsuo Kubota
• Support Opportunities: Research Projects - Thematic Grants