Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients

Author(s)

Signori Urbano, Ana Paula ^[1] ; Sassaki, Ligia Yukie ^[1] ; Dorna, Mariana de Souza ^[1] ; Presti, Paula Torres ^[1] ; de Barros Leite Carvalhaes, Maria Antonieta ^[2] ; Martini, Ligia Araujo ^[3] ; Anjos Ferreira, Ana Lucia ^[1]

Affiliation

^[1] Univ Estadual Paulista, UNESP, Fac Med, Dept Internal Med, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Fac Med, Nursing Dept, Botucatu, SP - Brazil

^[3] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Revista da Associação Médica Brasileira; v. 64, n. 2, p. 133-139, FEB 2018.
• Web of Science Citations: 1

Abstract

Summary Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], a1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent. (AU)

• FAPESP's process: 09/03449-3 - Assessment of dietary intake of antioxidants and the extension of intestinal lesions in patients with ulcerative colitis
• Grantee: Ana Paula Signori Urbano
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 07/07455-2 - Time-course of oxidative stress induced by doxorubicin in rats: damage mechanism
• Grantee: Ana Lucia do Anjos Ferreira
• Support Opportunities: Regular Research Grants