| Full text | |
| Author(s): |
Brito da Silva, Annielle Mendes
[1]
;
Silva-Goncalves, Laiz Costa
[1]
;
Oliveira, Fernando Augusto
[2]
;
Arcisio-Miranda, Manoel
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Paulo Unifesp, Dept Biofis, Lab Neurobiol Estrutural & Func LaNEF, Escola Paulista Med, Sao Paulo, SP - Brazil
[2] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Lab Neurobiol Celular & Mol LaNeC, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Molecular Neurobiology; v. 55, n. 7, p. 5490-5504, JUL 2018. |
| Web of Science Citations: | 3 |
| Abstract | |
Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of its complexity and heterogeneity, this tumor has become resistant to conventional therapies and the available treatment produces multiple side effects. Here, using multiple experimental approaches, we demonstrate that three mastoparan peptides-Polybia-MP1, Mastoparan X, and HR1-from solitary wasp venom exhibit potent anticancer activity toward human glioblastoma multiforme cells. Importantly, the antiglioblastoma action of mastoparan peptides occurs by membranolytic activity, leading to necrosis. Our data also suggest a direct relation between mastoparan membranolytic potency and the presence of negatively charged phospholipids like phosphatidylserine. Collectively, these data may warrant additional studies for mastoparan peptides as new agents for the treatment of glioblastoma multiforme brain tumor. (AU) | |
| FAPESP's process: | 12/02065-0 - Electrophysiology of antimicrobial peptides in planar lipid bilayers |
| Grantee: | Manoel de Arcisio Miranda Filho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives |
| Grantee: | Karin Do Amaral Riske |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/50336-2 - Interaction among hypometabolism, calcium dynamics and neuronal excitability: implications in the degenerative process of Alzheimer's Disease |
| Grantee: | Fernando Augusto de Oliveira Ribeiro |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 09/53840-0 - Fluorescence system for investigations of physiological and pathophysiological aspects in cellular models |
| Grantee: | Adriana Karaoglanovic Carmona |
| Support Opportunities: | Multi-user Equipment Program |