Copper(II) and silver(I) complexes with sulfamethizole: synthesis, spectroscopic characterization, ESI-QTOF mass spectrometric analysis, crystal structure and antibacterial activities

Author(s)

Yamamoto, Lais Megumi ^[1] ; Bormio Nunes, Julia Helena ^[1] ; Ribeiro, Marcos Antonio ^[2] ; da Costa Ferreira, Ana Maria ^[3] ; Lustri, Wilton Rogerio ^[4] ; Corbi, Pedro Paulo ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Inorgan Chem Dept, BR-13083970 Campinas, SP - Brazil

^[2] Fed Univ Espirito Santo UFES, Chem Dept, BR-29075910 Vitoria, ES - Brazil

^[3] Univ Sao Paulo, Dept Chem, BR-05508000 Sao Paulo, SP - Brazil

^[4] Univ Araraquara UNIARA, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Polyhedron; v. 138, p. 168-176, DEC 14 2017.
• Web of Science Citations: 4

Abstract

A ternary copper(II) complex with sulfamethizole (SMZ, C9H10N4O2S2) and 1,10-phenantroline (phen), {[}Cu(SMZ)(2)(phen)I, and a silver(I) complex with sulfamethizole, Ag-SMZ, are presented. Elemental analyses indicate a 2:1:1 SMZ/copper/phen composition for the {[}Cu(SMZ)(2)(phen)] complex and a 1:1 silver/SMZ composition for the Ag-SMZ complex. Mass spectrometric analyses permitted identifying the {[}Cu(SMZ)(2)(phen)+H](+) and {[}Ag(SMZ)+H](+) ions at m/z 782.0297 and m/z 378.9371, respectively, confirming the proposed comp(o)sitions. Theoretical isotopic patterns match with the experimental ones for the copper and silver complexes. H-1 and {[}N-15,H-1) HMBC nuclear magnetic resonance (NMR), and infrared (IR) spectroscopic measurements evidence the coordination of sulfamethizole to silver(I) by the SO2-N group, and indicate the participation of the 5-membered heterocyclic ring 5-methyl-1,3,4-thiadiazole in coordination. The {[}Cu(SMZ)(2)(phen)] crystal structure was determined by single crystal X-ray diffractometry, attesting the N-coordination of sulfamethizole to copper(II) by the nitrogen of the 5-methyl-1,3,4-thiadiazole heterocyclic ring. Electronic paramagnetic resonance (EPR) indicates a square pyramidal geometry around the copper(II) ion for the {[}Cu(SMZ)(2)(phen)] complex. Biological studies showed the antibacterial activity of the Ag-SMZ and {[}Cu(SMZ)(2)(phen)] complexes over Gram-positive and Gram-negative bacteria. Both complexes have shown to be more active against Gram-negative Pseudomonas aeruginosa ATCC bacterial strain, with minimum inhibitory concentration (MIC) values of 0.41 mmol L-1 for the silver(I) complex and 1.60 mmol L-1 for the copper(II) complex. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 15/09833-0 - Sustainable delivery system based on biocellulose/metallic complexes containing bioactive ligands
• Grantee: Wilton Rogério Lustri
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/01579-0 - Synthesis, characterization and antibacterial activity studies of Ag (i) and Cu (II) complexes with sulfamethizole
• Grantee: Lais Megumi Yamamoto
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 15/25114-4 - Synthesis of New Ag(I), Cu(II), Pd(II) and Pt(II) complexes based on sulfonamides and derivatives: antibacterial activities and application prospects on skin critically colonized wounds.
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants