Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species

Author(s)

dos Santos, Catarina ^[1] ; Galaverna, Renan S. ^[2] ; Angolini, Celio F. F. ^[2] ; Nunes, Vania V. A. ^[1] ; de Almeida, Luiz F. R. ^[3] ; Ruiz, Ana L. T. G. ^[4] ; de Carvalho, Joao E. ^[4] ; Duarte, Regina M. T. ^[5] ; Duarte, Marta C. T. ^[5] ; Eberlin, Marcos N. ^[2]

Affiliation

^[1] Univ Sao Paulo State UNESP, Fac Sci & Letters, Dept Biol Sci, BR-19806900 Assis - Brazil

^[2] Univ Campinas UNICAMP, Inst Chem, Thomson Mass Spectrometry Lab, BR-13083970 Campinas, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Dept Bot, Inst Biosci Botucatu, BR-18618970 Botucatu, SP - Brazil

^[4] Univ Campinas UNICAMP, Fac Pharmaceut Sci, POB 859, BR-13083859 Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Div Microbiol, CPQBA, POB 6171, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Molecules; v. 23, n. 5 MAY 2018.
• Web of Science Citations: 0

Abstract

Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(-)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 +/- 0.22 mu gmL(-1)), being slightly less active than quercetin and gallic acid (EC50 2.96 +/- 0.17 and 2.03 +/- 0.02 mu gmL(-1), respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 mu gmL(-1)). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 mu gmL(-1), respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants. (AU)

• FAPESP's process: 17/15610-0 - Biological potentialities in Myrtaceae
• Grantee: Catarina dos Santos
• Support Opportunities: Regular Research Grants