Natural infection of Neotropical bats with hantavirus in Brazil

Author(s):Show less -

Sabino-Santos, Jr., Gilberto ^[1] ; Motta Maia, Felipe Goncalves ^{[2, 1]} ; Martins, Ronaldo Braganca ^[1] ; Gagliardi, Talita Bianca ^[1] ; de Souza, William Marciel ^[1] ; Muylaert, Renata Lara ^[3] ; de Souza Luna, Luciano Kleber ^[1] ; Melo, Danilo Machado ^[1] ; Cardoso, Ricardo de Souza ^[1] ; Barbosa, Natalia da Silva ^[4] ; Pontelli, Marjorie Cornejo ^[1] ; Mamani-Zapana, Priscila Rosse ^[1] ; Vieira, Thallyta Maria ^[5] ; Melo, Norma Maria ^[6] ; Jonsson, Colleen B. ^[7] ; Goodin, Douglas ^[8] ; Salazar-Bravo, Jorge ^[9] ; Pinto dasilva, Luis Lamberti ^[4] ; Arruda, Eurico ^[1] ; Moraes Figueiredo, Luiz Tadeu ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Virol Res, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

^[3] Sao Paulo State Univ, Dept Ecol, Rio Claro - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol, Ribeirao Preto - Brazil

^[5] Univ Estadual Montes Claros, Dept Biol Sci, Montes Claros, MG - Brazil

^[6] Univ Fed Minas Gerais, Inst Biol Sci, Dept Parasitol, Belo Horizonte, MG - Brazil

^[7] Natl Inst Math & Biol Synth, Dept Microbiol, Knoxville, TN - USA

^[8] Kansas State Univ, Dept Geog, Manhattan, KS 66506 - USA

^[9] Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 - USA

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 8, JUN 13 2018.
• Web of Science Citations: 2

Abstract

Bats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks. (AU)

• FAPESP's process: 12/24150-9 - Research of virus in wild rodents, mosquitoes and ticks
• Grantee: William Marciel de Souza
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/06142-7 - Characterization of host cell factors involved in the budding and egress of Oropouche virus
• Grantee: Natalia da Silva Barbosa
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 12/03700-0 - Two issues regarding the human rhinoviruses: the inhibitory effect of 2A protease on the induction of interferon and a search for a natural animal host
• Grantee: Talita Bianca Gagliardi
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 13/06380-0 - Rhinovirus replication in explants of human tonsillar lymphoepithelial tissue infected ex vivo
• Grantee: Ronaldo Bragança Martins Júnior
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 11/19897-5 - Emerging picornaviruses and coronaviruses: association with respiratory pathogenesis in humans and detection in wild rodents
• Grantee: Luciano Kleber de Souza Luna
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 12/04096-0 - BAT diversity in Cerrado landscapes: is there a fragmentation threshold?
• Grantee: Renata de Lara Muylaert
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 15/05354-0 - Functional analysis of the m segment non-structural protein (NSm) of Orthobunyavirus Oropouche
• Grantee: Marjorie Cornejo Pontelli
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/02568-2 - Research on hantavirus and other viruses in wild small mammals and their ectoparasites
• Grantee: Gilberto Sabino dos Santos Junior
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 11/06810-9 - Detection and ecology of hantavirus among wild small mammals and their ectoparasites
• Grantee: Gilberto Sabino dos Santos Junior
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/02438-6 - Studies with Bunyaviridae that produce human disease
• Grantee: Luiz Tadeu Moraes Figueiredo
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 11/22663-6 - Study of the occurence of arboviroses in wild animals and mosquitoes in Brazilian biomes and agroecosystems
• Grantee: Felipe Gonçalves Motta Maia
• Support type: Scholarships in Brazil - Doctorate