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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Magnetically triggered release of amoxicillin from xanthan/Fe3O4/albumin patches

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Bueno, Pedro V. A. [1] ; Hilamatu, Karina C. P. [1] ; Carmona-Ribeiro, Ana M. [2] ; Petri, Denise F. S. [1]
Total Authors: 4
[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 115, p. 792-800, AUG 2018.
Web of Science Citations: 3

This work was motivated by the need of stimuli responsive drug carriers, which can be activated by low cost non-invasive stimuli such as external magnetic field (EMF). Thus, novel antimicrobial materials based on xanthan gum (XG), magnetic nanoparticles (MNP), bovine serum albumin (BSA) and amoxicillin (Amox) were designed in order to promote the release of Amox under magnetic stimuli. Firstly, surfaces with different functionalities were prepared by sequential deposition of thin layers on Si wafers and characterized by means of ellipsometry and atomic force microscopy. Amox adsorbed preferentially onto XG or BSA films. In solution, favorable interactions between Amox and BSA were evidenced by substantial changes in the BSA secondary structure, as revealed by circular dichroism. Patches of XG and XG/MNP/BSA were immersed in 2 g L-1 Amox, yielding 10 +/- 3 and 17 +/- 4 mu g/cm(3) Amox loading, respectively. The inclusion of 0.2 wt% Fe3O4 in the patches and their exposure to EMF enabled in vitro release of Amox, at pH 5.5 and 0.02 mol L-1 NaCI, following the quasi-Fickian behavior. Amox diffused from XG/MNP/BSA patches in agar medium containing Staphylococcus aureus and Escherichia coli, inhibiting their growth. The inhibition of E. coli growth was particularly efficient under EMF. (C) 2018 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 16/08750-7 - Hybrid complexes of polyelectrolytes and magnetite for control release of amoxycillin
Grantee:Pedro Vinicius de Assis Bueno
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/25103-2 - Magnetic stimuli in biotechnological processes
Grantee:Denise Freitas Siqueira Petri
Support type: Regular Research Grants