Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae)

Author(s)

Ccana-Ccapatinta, Gari V. ^[1] ; Monge, Marcelo ^[2] ; Ferreira, Paola L. ^[3] ; Da Costa, Fernando B. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, Lab Pharmacognosy, AsterBioChem Res Team, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Campinas UNICAMP, Inst Biol, Grad Program Plant Biol, R Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Lab Plant Systemat, Dept Biol, Fac Philosophy Sci & Letters Ribeirao Preto FFCLR, Ave Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: PHYTOCHEMISTRY REVIEWS; v. 17, n. 3, p. 471-489, JUN 2018.
• Web of Science Citations: 1

Abstract

The subfamily Barnadesioideae (Asteraceae) constitutes a group of spiny plants that are entirely restricted to South America and currently encompasses 92 species distributed in nine genera. Barnadesioideae is particularly interesting because this subfamily constitutes the sister group of all other Asteraceae, and provides insights into the early evolution of Asteraceae. The present work summarizes the current knowledge of the chemistry and medicinal uses of Barnadesioideae. The up-to-date phytochemical profile of Barnadesioideae is composed of phenolic compounds, flavonoids, and triterpenoids, representing 39 different compounds described in 45 species of the subfamily. The presumable absence of sesquiterpene lactones-the typical Asteraceae taxonomical markers-in members of Barnadesioideae is also discussed. A few members of the genera Barnadesia, Dasyphyllum, and more frequently, Chuquiraga, are reported in the traditional medicine of Argentina, Brazil, Bolivia, Chile, Colombia, Ecuador, and Peru, where they are known for their antitussive, expectorant, anti-inflammatory, and many other properties. Chuquiraga jussieui, Chuquiraga spinosa, and Chuquiraga weberbaueri are species frequently sold in medicinal plant markets of Ecuador and Peru, where they are commonly recommended for the relief of genitourinary and reproductive disorders in women and men. Some phytopharmaceuticals containing C. spinosa are also marketed in Europe and North America. Further phytochemical studies on the members of Barnadesioideae would be of great interest for the chemotaxonomy of the family Asteraceae. Moreover, profiling the phytochemical composition of those medically important Barnadesioideae would support their uses in traditional medicine. (AU)

• FAPESP's process: 14/26866-7 - Metabolomics, enzymatic targets and in silico tools in the search of bioactive compounds from plants
• Grantee: Fernando Batista da Costa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/16850-6 - Metabolomic and chemometric approach for the study of chemotaxonomy, authentication and quality control of the species of the subfamily Barnadesioideae (Asteraceae)
• Grantee: Gari Vidal Ccana Ccapatinta
• Support Opportunities: Scholarships in Brazil - Doctorate