| Full text | |
| Author(s): |
Rodrigues, Evandra Strazza
[1, 2]
;
Favarin, Maria do Carmo
[2]
;
de Macedo, Mayra Dorigan
[1, 2]
;
Otaguiri, Katia Kaori
[1, 2]
;
Orellana, Maristela Delgado
[3, 2]
;
Takayanagui, Osvaldo Massaiti
[3]
;
Bonini Palma, Patricia Vianna
[2]
;
Slavov, Svetoslav Nanev
[3, 2]
;
Covas, Dimas Tadeu
[3, 2]
;
Kashima, Simone
[1, 2]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Sao Paulo - Brazil
[2] Univ Sao Paulo, Reg Blood Ctr Ribeirao Preto, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Internal Med, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | VIROLOGY; v. 519, p. 145-155, JUN 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
The bone marrow (BM) biology during HTLV-1 infection is obscure. In this study, we investigated BM mononuclear cells and mesenchymal stromal cells (MSC) from HTLV-1 asymptomatic and symptomatic individuals. An infiltration of CD4(+)T-cell lymphocytes in the BM of HTLV-1-infected individuals was observed when compared to healthy controls. The provirus detection in the BM CD4(+)T cells confirmed the presence of integrated HTLV DNA. In regard to MSC, we observed that the number of fibroblast progenitor cells was lower in HTLV-1 infected individuals than in healthy controls. Isolated HTLV-1 infected BM-MSC demonstrated surface expression markers and in vitro differentiation potential similar to uninfected individuals. The presence of HTLV-1 proviral DNA in the BM-MSC of HTLV-1-infected patients was demonstrated but no p19 antigen was detected in supernatant from cultured MSC. We suppose that HTLV-1 infects human MSC probably by cell-to-cell contact from the infected CD4(+)T-lymphocytes infiltrated into the bone marrow. (AU) | |
| FAPESP's process: | 13/08135-2 - CTC - Center for Cell-Based Therapy |
| Grantee: | Dimas Tadeu Covas |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |