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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevalence and reactivity of anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in Brazilian patients with dermatomyositis

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Author(s):
Isabela Bruna Pires Borges [1] ; Marilda Guimarães Silva [2] ; Samuel Katsuyuki Shinjo [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina. Division of Rheumatology - Brasil
[2] Universidade de São Paulo. Faculdade de Medicina. Division of Rheumatology - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina. Division of Rheumatology - Brasil
Total Affiliations: 3
Document type: Journal article
Source: ANAIS BRASILEIROS DE DERMATOLOGIA; v. 93, n. 4, p. 517-523, 2018-08-00.
Abstract

Abstract: Background: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. Objectives: To analyze this autoantibody in the Brazilian population. Methods: This was a single-center cross-sectional study in which 131 consecutive adult patients (109 dermatomyositis and 22 clinically amyopathic dermatomyositis) with active disease were evaluated from 2000 to 2016. Analysis of the anti-MDA-5 autoantibody was performed by ELISA. Results: The presence of this autoantibody was observed in 14.7% and 22.7% of patients with dermatomyositis and clinically amyopathic dermatomyositis, respectively. In the case of dermatomyositis, the autoantibody was associated less frequently with Raynaud’s phenomenon and periungual hyperemia (P<0.05). In clinically amyopathic dermatomyositis, the presence of this autoantibody was not associated statistically with any demographic, clinical, laboratory, or imaging characteristics. Study limitations: The cross-sectional study design did not allow establishing a temporal correlation between anti-MDA-5 autoantibody and various study variables. In addition, pulmonary function tests were not performed in the patients. Conclusions: The frequency of anti-MDA-5 autoantibody was comparable to that of other populations with dermatomyositis, but with a different reactivity than described in the literature. In addition, there was a phenotypic variability between our patients with clinically amyopathic dermatomyositis and those described in the literature. Further studies are needed to confirm the current study’s findings and elucidate this autoantibody’s reactivity in Brazilians with idiopathic inflammatory myopathies. (AU)

FAPESP's process: 14/09079-1 - Impact of corticosteroids in the inflammatory process of muscle biopsies of dermatomyositis and polymyositis
Grantee:Samuel Katsuyuki Shinjo
Support Opportunities: Regular Research Grants
FAPESP's process: 15/12628-0 - Characterization of autoantibody anti-melanoma differentiation associated gene 5 (anti-MDA5) in patients with dermatomyositis and polymyositis
Grantee:Isabela Bruna Pires Borges
Support Opportunities: Scholarships in Brazil - Scientific Initiation