Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Comparative Study of Hummingbirds and Chickens Provides Mechanistic Insight on the Histidine Containing Dipeptide Role in Skeletal Muscle Metabolism

Full text
Author(s):
Dolan, E. [1, 2] ; Saunders, B. [1, 2] ; Dantas, W. S. [1, 2] ; Murai, I. H. [1, 2] ; Roschel, H. [1, 2] ; Artioli, G. G. [1, 2] ; Harris, R. [3] ; Bicudo, J. E. P. W. [4] ; Sale, C. [5, 6, 7] ; Gualano, B. [1, 2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Rheumatol Div, Appl Physiol & Nutr Res Grp, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, FMUSP, Sao Paulo, SP - Brazil
[3] Junipa Ltd, Newmarket, Suffolk - England
[4] Univ Wollongong, Sch Biol Sci, Wollongong, NSW - Australia
[5] Nottingham Trent Univ, Sport Hlth & Performance Enhancement Res Ctr, Nottingham - England
[6] Nottingham Trent Univ, Musculoskeletal Physiol Res Grp, Nottingham - England
[7] Nottingham Trent Univ, Sch Sci & Technol, Nottingham - England
Total Affiliations: 7
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, OCT 3 2018.
Web of Science Citations: 2
Abstract

Histidine containing dipeptides (HCDs) have numerous ergogenic and therapeutic properties, but their primary role in skeletal muscle remains unclear. Potential functions include pH regulation, protection against reactive oxygen/nitrogen species, or Ca2+ regulation. In recognition of the challenge of isolating physiological processes in-vivo, we employed a comparative physiology approach to investigate the primary mechanism of HCD action in skeletal muscle. We selected two avian species (i.e., hummingbirds and chickens), who represented the extremes of the physiological processes in which HCDs are likely to function. Our findings indicate that HCDs are non-essential to the development of highly oxidative and contractile muscle, given their very low content in hummingbird skeletal tissue. In contrast, their abundance in the glycolytic chicken muscle, indicate that they are important in anaerobic bioenergetics as pH regulators. This evidence provides new insights on the HCD role in skeletal muscle, which could inform widespread interventions, from health to elite performance. (AU)

FAPESP's process: 16/10993-5 - Effects of exercise training in patients undergoing bariatric surgery: a randomized and clinical trial
Grantee:Hamilton Augusto Roschel da Silva
Support type: Regular Research Grants
FAPESP's process: 17/09635-0 - Factors determining the carnosine content of human skeletal muscle: influence of age and sex
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/11328-2 - Carnosine metabolism in skeletal muscle: a multi-approach study. Substudy 3: exploring carnosine role in skeletal muscle
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Young Researchers