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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise activates the hypothalamic S1PR1-STAT3 axis through the central action of interleukin 6 in mice

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Author(s):
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Silva, Vagner R. R. [1, 2] ; Micheletti, Thayana O. [1] ; Katashima, Carlos K. [1] ; Lenhare, Luciene [1, 2] ; Morari, Joseane [3] ; Moura-Assis, Alexandre [3] ; de Lima-Junior, Jose C. [3] ; Camargo, Juliana A. [1] ; Passos, Gabriela R. [1] ; Gaspar, Rodrigo S. [2] ; Velloso, Licio A. [3] ; Saad, Mario J. [1] ; da Silva, Adelino S. R. [4, 5, 6] ; Moura, Leandro P. [2] ; Cintra, Dennys E. [5] ; Pauli, Jose R. [2, 7] ; Ropelle, Eduardo R. [1, 2, 7, 3]
Total Authors: 17
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, BR-13484350 Limeira, SP - Brazil
[3] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Lab Cell Signaling, Campinas, SP - Brazil
[4] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil
[5] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom LabGeN, Limeira, SP - Brazil
[6] Univ Sao Paulo, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
[7] Univ Estadual Campinas, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Limeira, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Journal of Cellular Physiology; v. 233, n. 12, p. 9426-9436, DEC 2018.
Web of Science Citations: 0
Abstract

Hypothalamic sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled receptor 1 of sphingosine-1-phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate the role of interleukin 6 (IL-6) associated with acute physical exercise in the control of the hypothalamic S1PR1-signal transducer and activator of transcription 3 (STAT3) axis. Acute exercise session and an intracerebroventricular IL-6 injection increased S1PR1 protein content and STAT3 phosphorylation in the hypothalamus of lean and obese mice accompanied by a reduction in food consumption. Transcriptome analysis indicated a strong positive correlation between Il-6 and S1pr1 messenger RNA in several tissues of genetically diverse BXD mice strains and humans, including in the hypothalamus. Interestingly, exercise failed to stimulate the S1PR1-STAT3 axis in IL-6 knockout mice and the disruption of hypothalamic-specific IL-6 action blocked the anorexigenic effects of exercise. Taken together, our results indicate that physical exercise modulates the S1PR1 protein content in the hypothalamus, through the central action of IL-6. (AU)

FAPESP's process: 16/01089-3 - Evaluation of mtUPR and mito-nuclear imbalance in response to physical training: A multiorganic approach.
Grantee:Eduardo Rochete Ropelle
Support Opportunities: Regular Research Grants
FAPESP's process: 13/20052-5 - EFFECTS OF PHYSICAL EXERCISE ON THE SENSITIVITY OF GLUCOSE HYPOTHALAMUS IN RATS: ROLE OF PROTEIN ALPHA HIF2
Grantee:Vagner Ramon Rodrigues Silva
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/09656-0 - Characterization of hypothalamic S1PR1 in the control of food intake in rodents
Grantee:Eduardo Rochete Ropelle
Support Opportunities: Research Grants - Young Investigators Grants