| Full text | |
| Author(s): |
Frigero, Marcelo
[1]
;
dos Santos, Solange Almeida
[2]
;
Serra, Andrey Jorge
[1]
;
Monteiro Machado, Caroline dos Santos
[2]
;
Portes, Leslie Andrews
[3, 4]
;
Ferreira Tucci, Paulo Jose
[3]
;
Silva, Flavio
[3, 4]
;
Leal-Junior, Ernesto Cesar
[2]
;
Camillo de Carvalho, Paulo de Tarso
[1, 2]
Total Authors: 9
|
| Affiliation: | [1] Univ Nove de Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, Sao Paulo, SP - Brazil
[2] Univ Nove de Julho UNINOVE, Postgrad Program Rehabil Sci, Rua Vergueiro 235, Sao Paulo, SP - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Dept Cardiol, Sao Paulo, SP - Brazil
[4] Adventist Univ Sao Paulo UNASP, Dept Cardiol, Sao Paulo, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Lasers in Medical Science; v. 33, n. 8, p. 1781-1790, NOV 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
This study aimed to determine whether photobiomodulation therapy (PBMT) in diabetic rats subjected to high-intensity exercise interferes with the expression of the oxidative stress marker in the gastrocnemius muscle. Twenty-four male Wistar rats were included in this study comprising 16 diabetic and eight control rats. The animals were allocated into three groupscontrol, diabetic fatigue, and diabetic PBMT fatigue groups. Diabetes was induced via the intraperitoneal administration of streptozotocin (50mg/kg). We subsequently assessed blood lactate levels and PBMT. The animals of the diabetic fatigue group PBMT were irradiated before the beginning of the exercises, with dose of 4J and 808nm, were submitted to treadmill running with speed and gradual slope until exhaustion, as observed by the maximum volume of oxygen and lactate level. The animals were euthanized and muscle tissue was removed for analysis of SOD markers, including catalase (CAT), glutathione peroxidase (GPx), and 2-thiobarbituric acid (TBARS) reactive substances. CAT, SOD, and GPx activities were significantly higher in the diabetic PBMT fatigue group (p<0.05) than in the diabetic fatigue group. Outcomes for the diabetic PBMT fatigue group were similar to those of the control group (p>0.05), while their antioxidant enzymes were significantly higher than those of the diabetic fatigue group. PBMT mitigated the TBARS concentration (p>0.05). PBMT may reduce oxidative stress and be an alternative method of maintaining physical fitness when subjects are unable to perform exercise. However, this finding requires further testing in clinical studies. (AU) | |
| FAPESP's process: | 15/13677-4 - EFFECTS OF LOW-LEVEL LASER THERAPY OF THE BIOAVAILABILITY STEM CELLS DERIVED FROM MESENCHYMAL ADIPOCYTES AND IMPLEMENTED ON KNEES WITH EXPERIMENTAL OSTEOARTHRITIS |
| Grantee: | Paulo de Tarso Camillo de Carvalho |
| Support Opportunities: | Regular Research Grants |