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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Palmitoleic Acid has Stronger Anti-Inflammatory Potential in Human Endothelial Cells Compared to Oleic and Palmitic Acids

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Author(s):
de Souza, Camila Oliveira [1] ; Valenzuela, Carina A. [2, 3] ; Baker, Ella J. [2] ; Miles, Elizabeth A. [2] ; Neto, Jose C. Rosa [1] ; Calder, Philip C. [2, 4, 5]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Cell & Dev Biol, 1524 Lineu Prestes Ave, Sao Paulo - Brazil
[2] Univ Southampton, Human Dev & Hlth Acad Unit, Fac Med, Tremona Rd, Southampton S016 6HT, Hants - England
[3] Univ Valparaiso, Sch Nutr, Fac Pharm, 1093 Gran Bretana Ave, Valparaiso - Chile
[4] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Tremona Rd, Southampton S016 6HT, Hants - England
[5] Univ Southampton, Tremona Rd, Southampton S016 6HT, Hants - England
Total Affiliations: 5
Document type: Journal article
Source: MOLECULAR NUTRITION & FOOD RESEARCH; v. 62, n. 20 OCT 2018.
Web of Science Citations: 2
Abstract

Scope: Fatty acids (FAs) may affect endothelial cell (EC) function, influencing atherogenesis and inflammatory processes. Palmitoleic acid (POA) has been described as an anti-inflammatory FA. However, its effects on ECs are underexplored. This study compares the effects of POA with those of palmitic acid (PA) and oleic acid (OA) on EC inflammatory responses. Methods and Results: EAHy926 cells (EC lineage) are exposed to PA, OA, or POA, and stimulated with tumor necrosis factor (TNF)-alpha. Associated with the FA's own incorporation, PA induces a twofold increase in arachidonic acid, while POA increases the amount of cis-vaccenic acid. PA, but not OA, enhances the production of IL-6 and IL-8 in response to TNF-alpha. In contrast, POA decreases production of monocyte chemotactic protein (MCP)-1, IL-6, and IL-8 compared to PA. TNF-alpha increases surface intercellular adhesion molecule-1 expression previously decreased by POA. TNF-alpha stimulation increases the expression of NF kappa B, cyclooxygenase (COX)-2, MCP-1, and IL-6 genes and reduces the expression of peroxisome proliferator-activated receptor (PPAR)-alpha gene. PA enhances the expression of MCP-1, IL-6, and COX-2 genes, while POA downregulates these genes, decreases expression of NF kappa B, and upregulates PPAR-alpha gene expression. Conclusion: POA has anti-inflammatory effects on ECs stimulated with TNF-alpha and may counter endothelial dysfunction. (AU)

FAPESP's process: 13/04765-1 - Palmitoleic acid supplementation effects on immune-metabolics alterations induced by high fat diet on PPAR knockout mice
Grantee:Camila Oliveira de Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/01409-8 - The caracterization of antiinflammatory effect of palmitoleic acid suplemmentation in hepatic inflammation; The role of PPARs.
Grantee:José Cesar Rosa Neto
Support type: Regular Research Grants
FAPESP's process: 15/06376-8 - EFFECT OF PALMITIC, OLEIC AND PALMITOLEIC ACIDS ON INFLAMMATORY RESPONSES OF CULTURED HUMAN ENDOTHELIAL CELLS
Grantee:Camila Oliveira de Souza
Support type: Scholarships abroad - Research Internship - Doctorate