| Full text | |
| Author(s): |
Joselevitch, Julia A.
[1]
;
Barra, Camila N.
[2, 1]
;
Vargas, Thiago Henrique M.
[1]
;
Pulz, Lidia H.
[2, 1]
;
Nishiya, Adriana T.
[3]
;
Kleeb, Silvia Regina
[4]
;
Xavier, Jose Guilherme
[5]
;
Catao-Dias, Jose Luiz
[2]
;
Strefezzi, Ricardo F.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Dept Med Vet, LOCT, Fac Zootecnia & Engn Alimentos, Av Duque de Caxias Norte 225, BR-13635 Pirassununga, SP - Brazil
[2] Univ Sao Paulo, Dept Patol, Fac Med Vet & Zootecnia, Sao Paulo - Brazil
[3] Univ Anhembi Morumbi, Sao Paulo, SP - Brazil
[4] Univ Metodista Sao Paulo, Sao Bernardo Do Campo, SP - Brazil
[5] Univ Paulista, Sao Paulo, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | VETERINARY PATHOLOGY; v. 55, n. 6, p. 849-852, NOV 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Mast cell tumors are one of the most frequent skin tumors in dogs. Treatment decisions often depend on a wide range of clinical information and the main criteria for prognostic formulation are histological grade, mitotic count, Ki67 index, and KIT immunostaining pattern. NANOG is a pluripotency factor expressed by normal and cancer stem cells, which is a prognostic marker and a potential therapeutic target for several human tumors. In the present study, mast cell tumor samples from 41 dogs were evaluated for NANOG and Ki67 by immunohistochemistry. All samples were positive for NANOG but its expression was not correlated with Ki67 index and no significant differences were found with respect to histopathological grades, disease-related mortality, or survival. Our results suggest that, although related to pluripotency, NANOG expression does not correlate with proliferative activity, and is not a reliable prognostic factor for canine cutaneous mast cell tumors. (AU) | |
| FAPESP's process: | 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators |
| Grantee: | Ricardo de Francisco Strefezzi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/20872-5 - Expression of nanog pluripotency factor in canine cutaneous mast cell tumors |
| Grantee: | Julia Antongiovanni Joselevitch |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 16/03862-1 - Characterization of cancer associated fibroblasts and its influence on canine neoplasms |
| Grantee: | Ricardo de Francisco Strefezzi |
| Support Opportunities: | Regular Research Grants |