Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition

Author(s)

Vercesi, Anibal E. ^[1] ; Castilho, Roger F. ^[1] ; Kowaltowski, Alicia J. ^[2] ; de Oliveira, Helena C. F. ^[3] ; de Souza-Pinto, Nadja C. ^[2] ; Figueira, Tiago R. ^[4] ; Busanello, Estela N. B. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, Campinas, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Dept Biol Estrutural & Func, Campinas, SP - Brazil

^[4] Univ Sao Paulo, Escola Educ Fis & Esporte Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: Free Radical Biology and Medicine; v. 129, p. 1-24, DEC 2018.
• Web of Science Citations: 8

Abstract

Mitochondria possess a Ca2+ transport system composed of separate Ca2+ influx and efflux pathways. Intramitochondrial Ca2+ concentrations regulate oxidative phosphorylation, required for cell function and survival, and mitochondrial redox balance, that participates in a myriad of signaling and damaging pathways. The interaction between Ca2+ accumulation and redox imbalance regulates opening and closing of a highly regulated inner membrane pore, the membrane permeability transition pore (PTP). In this review, we discuss the regulation of the PTP by mitochondrial oxidants, reactive nitrogen species, and the interactions between these species and other PTP inducers. In addition, we discuss the involvement of mitochondrial redox imbalance and PTP in metabolic conditions such as atherogenesis, diabetes, obesity and in mtDNA stability. (AU)

• FAPESP's process: 17/17728-8 - Mitochondrial function and dysfunction: implications for aging and associated diseases
• Grantee: Aníbal Eugênio Vercesi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
• Grantee: Aníbal Eugênio Vercesi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 06/59786-0 - Energetic metabolism, intracellular homeostasis of CA2+ and mitochondrial oxidative stress in cell death
• Grantee: Aníbal Eugênio Vercesi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/11261-2 - Cellular antioxidant systems response to mitochondrial oxidative stress induced by statins in skelton muscle of hypercholesterolemic mice
• Grantee: Estela Natacha Brandt Busanello
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC