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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles

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Author(s):
Affonso de Oliveira, Jessica Fernanda [1, 2, 3, 4] ; Scheffer, Francine Ramos [1, 2, 3] ; Landis, Ryan F. [4] ; Neto, Erico Teixeira [2, 3] ; Rotello, Vincent M. [4] ; Cardoso, Mateus Borba [1, 2, 3]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas UNICAMP, IQ, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
[2] CNPEM, Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[3] CNPEM, LNLS, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
[4] Univ Massachusetts Amherst, Dept Chem, 710 North Pleasant St, Amherst, MA 01003 - USA
Total Affiliations: 4
Document type: Journal article
Source: ACS APPLIED MATERIALS & INTERFACES; v. 10, n. 49, p. 41917-41923, DEC 12 2018.
Web of Science Citations: 0
Abstract

Protein coronas form on the surfaces of nanomaterials in biological fluids. This layer of proteins affects the properties of nanomaterials, altering their behavior and masking engineered functionality. The use of nonfouling moieties reduces or prevents corona formation; however, these ligands typically complicate functionalization. We present here a surface modification strategy for silica nanoparticles using specific molar ratios of zwitterionic and amine moieties. Through proper balance of ligands, we were able to generate particles that featured reactive ``handles{''}, while retaining nonfouling properties, high hemocompatibility, and low cytotoxicity. (AU)

FAPESP's process: 15/21918-1 - Improvement of cell targeting through protein corona-resistant functionalization on doxorubicin and curcumin loaded mesoporous silica nanoparticles
Grantee:Jessica Fernanda Affonso de Oliveira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support type: Regular Research Grants
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/22429-9 - Synthesis of mesoporous silica nanoparticles functionalized with monoclonal antibodies: an alternative to Hodgkin (HL) and anaplastic large cell CD30+ (ALCL - CD30+) lymphomas treatment
Grantee:Jessica Fernanda Affonso de Oliveira
Support type: Scholarships in Brazil - Doctorate