Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles

Author(s)

Affonso de Oliveira, Jessica Fernanda ^{[1, 2, 3, 4]} ; Scheffer, Francine Ramos ^{[1, 2, 3]} ; Landis, Ryan F. ^[4] ; Neto, Erico Teixeira ^{[2, 3]} ; Rotello, Vincent M. ^[4] ; Cardoso, Mateus Borba ^{[1, 2, 3]}

Affiliation

^[1] Univ Estadual Campinas UNICAMP, IQ, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil

^[2] CNPEM, Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil

^[3] CNPEM, LNLS, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil

^[4] Univ Massachusetts Amherst, Dept Chem, 710 North Pleasant St, Amherst, MA 01003 - USA

• Document type: Journal article
• Source: ACS APPLIED MATERIALS & INTERFACES; v. 10, n. 49, p. 41917-41923, DEC 12 2018.
• Web of Science Citations: 1

Abstract

Protein coronas form on the surfaces of nanomaterials in biological fluids. This layer of proteins affects the properties of nanomaterials, altering their behavior and masking engineered functionality. The use of nonfouling moieties reduces or prevents corona formation; however, these ligands typically complicate functionalization. We present here a surface modification strategy for silica nanoparticles using specific molar ratios of zwitterionic and amine moieties. Through proper balance of ligands, we were able to generate particles that featured reactive ``handles{''}, while retaining nonfouling properties, high hemocompatibility, and low cytotoxicity. (AU)

• FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
• Grantee: Watson Loh
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
• Grantee: Mateus Borba Cardoso
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/22429-9 - Synthesis of mesoporous silica nanoparticles functionalized with monoclonal antibodies: an alternative to Hodgkin (HL) and anaplastic large cell CD30+ (ALCL - CD30+) lymphomas treatment
• Grantee: Jessica Fernanda Affonso de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/21918-1 - Improvement of cell targeting through protein corona-resistant functionalization on doxorubicin and curcumin loaded mesoporous silica nanoparticles
• Grantee: Jessica Fernanda Affonso de Oliveira
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate