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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control

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Author(s):
Yonamine, Caio Y. [1] ; Alves-Wagner, Ana B. [1] ; Esteves, V, Joao ; Okamoto, Maristela M. [2] ; Correa-Giannella, Maria L. [3, 4] ; Giannella-Neto, Daniel [3] ; Machado, Ubiratan F. [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, SP - Brazil
[2] Esteves, Joao, V, Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Nove Julho Uninove, Programa Posgrad Med, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Carboidratos & Radioimunoensaio, Fac Med, LIM 18, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 481, p. 26-34, FEB 5 2019.
Web of Science Citations: 0
Abstract

Expression of the glucose transporter GLUT4, encoded by Slc2a4 gene, is reduced in both type 1 and type 2 diabetes (T1D and T2D), contributing to glycemic impairment. The present study investigated epigenetic regulations at the Slc2a4 promoter in skeletal muscle of T1D- and T2D-like experimental models. Slc2a4/GLUT4 repression was observed in T1D and T2D and that was reversed by insulin and resveratrol treatments, respectively. In both T1D-like and T2D-like animals, tri-methylation at lysine 9 of histone 3 (H3K9me3) increased in the Slc2a4 enhancer segment, whereas MEF2A/D binding into this segment was reduced; all effects were reversed by respective treatments. This study reveals that increased H3K9me3 in the Slc2a4 promoter enhancer segment contributes to reduce GLUT4 expression in skeletal muscle and to worse glycemic control in diabetes, pointing to the H3K9me3 of Slc2a4 promoter as a potential target for development of new approaches for treating diabetes. (AU)

FAPESP's process: 12/20432-0 - INVESTIGATION OF miRNAS POTENTIALLY INVOLED IN THE SLC2A4-GLUT4 EXPRESSION REGULATION IN SKELETAL MUSCLE OF DIABETIC RATS
Grantee:João Victor Del Conti Esteves
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/15603-0 - Unraveling mechanisms of glycemic control and chronic complications of Diabetes mellitus: contributions to human health
Grantee:Ubiratan Fabres Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/26616-8 - cAMP responsive element (CRE) participation in the SLC2A4 regulation by sympathetic nervous system
Grantee:Ana Bárbara Teixeira Alves Wagner
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/04831-1 - New players in glycemic control and chronic complications of Diabetes mellitus: preventive and therapeutic perspectives
Grantee:Ubiratan Fabres Machado
Support type: Research Projects - Thematic Grants