Conforto, Adriana Bastos
Brunoni, Andre Russowsky
Leite, Claudia da Costa
[6, 7, 8]
Filho, Geraldo Busatto
[6, 7, 2, 3]
Lotufo, Paulo A.
Bensenor, Isabela M.
Goulart, Alessandra Carvalho
Total Authors: 10
 Univ Sao Paulo, Hosp Univ, Ctr Clin & Epidemiol Res, Av Prof Lineu Prestes 2565, Butantan Cidade Univ, BR-05508000 Sao Paulo, SP - Brazil
 Univ Sao Paulo, Med Sch, Dept Psiquiatria, Lab Psychiat Neuroimaging LIM21, Sao Paulo - Brazil
 Univ Sao Paulo, Med Sch, Hosp Clin, Inst Psychiat, Sao Paulo - Brazil
 Univ Sao Paulo, Med Sch, Lab Med Invest Psychopharmacol & Clin Psychophysi, Sao Paulo - Brazil
 Univ Sao Paulo, Med Sch, Hosp Clin, Dept Neurol, Sao Paulo - Brazil
 Univ Sao Paulo, NAPNA, Sao Paulo - Brazil
 Univ Sao Paulo, Med Sch, Sao Paulo - Brazil
 Univ Sao Paulo, Hosp Clin, Inst Radiol & Oncol, Sao Paulo - Brazil
Total Affiliations: 8
Journal of Affective Disorders;
FEB 15 2019.
Web of Science Citations:
Background: Post-stroke depression (PSD) and cognitive impairment (PCI) are common conditions. This study aims to describe the protocol and preliminary findings of an investigation into factors associated with PSD and PCI 1-3 months after stroke (subacute phase) in survivors from the Study of Stroke Mortality and Morbidity (EMMA study). Methods: Stroke patients underwent to clinical and neurological evaluations on admission to hospital. Cerebral magnetic resonance and biomarkers (serotonin, BDNF, IL-6 and IL-18) were carried out in the subacute phase. DSM-IV major depression for the diagnosis of PSD, cognitive functioning for the diagnosis of PCI and functional disability were also recorded at same time. Results: Of the 103 eligible patients, 85.4% had ischemic stroke and 73.7% had first-ever stroke. In the subacute phase, 27.2% had PCI and 13.6% had current PSD (5.8% with `first episode' and 7.8% with `recurrent' depression). PCI was associated with low education (0-7 years of formal education: 75%) and ageing (median age: 70; interquartile range: 59-75 y-old). Left-sided stroke was more frequently associated with increased PCI than right-sided stroke (71.4% vs. 28.4%, p = 0.005). PSD was neither associated with stroke laterality nor tentorial area. Overall, biomarkers levels were not alterated in patients with PSD and PCI. Limitations: Findings are based on small sample and less disabled stroke participants, e.g. those without aphasia and deafness. Conclusions: Findings reinforce the need of early recognition and rehabilitation of PCI and PSD, mainly among those less educated and with left-sided stroke. PSD might occur through a pathophysiological pathway other than classical depression. (AU)