| Full text | |
| Author(s): |
Cruz, Marcos A. E.
[1]
;
Tovani, Camila B.
[1]
;
Favarin, Bruno Z.
[1]
;
Soares, Mariana P. R.
[2]
;
Fukada, Sandra Y.
[2]
;
Ciancaglini, Pietro
[1]
;
Ramos, Ana P.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF MATERIALS CHEMISTRY B; v. 7, n. 5, p. 823-829, FEB 7 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Strontium ranelate (SrR) has been used as the ultimate choice for osteoporosis treatment. However, the development of more tolerable and bioactive Sr2+ carriers is still a need. The design of Sr2+-based platforms has moved towards the obtention of anion carriers that can also exhibit a positive effect on bone metabolism. In this sense, we used morin, a natural flavonoid, as a new arrangement for Sr2+ carriage in the synthesis of an Sr2+ complex. It has been claimed that phenolic compounds promote bone health. Therefore, we hypothesized that the association of Sr2+ with morin could improve its anabolic effects. Complexes with the general formula {[}(C15H9O7)Sr(H2O)(2)]Cl center dot 3H(2)O were synthesized and characterized by elemental analysis, thermogravimetry, UV-Vis and infrared absorption spectroscopies and H-1-nuclear magnetic resonance. We showed that the complexation between morin and Sr2+ occurred among the 3-OH and 4C=O groups of morin. Preosteoclasts cultures with the Sr-morin complex exhibited a reduced osteoclast differentiation rate and sustained osteoblast mineralization ability. The response of Sr-morin was higher than that observed for SrR at the same concentration range. Considering the above-mentioned observations, the Sr-morin complex could be an interesting approach to be further exploited not only as an alternative treatment for osteoporosis but also in the design of materials for faster osteointegration. (AU) | |
| FAPESP's process: | 15/09034-0 - The role of O-glycosylation on the modulation of osteoclastogenesis and bone resorption |
| Grantee: | Sandra Yasuyo Fukada Alves |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/08892-9 - Bioactive surfaces designed from Langmuir-Blodgett Films and Biominerals |
| Grantee: | Ana Paula Ramos |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/24249-0 - Association of osteogenic proteins in biominerals and metallic oxides doped with rare-earth: interaction with membrane models systems. |
| Grantee: | Camila Bussola Tovani |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/21236-0 - Extracellular matrix vesicles (MVs) mimetic systems to study the regulation of the biomineralization process: proteoliposomes containing NPP1 and Annexin V |
| Grantee: | Pietro Ciancaglini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/08774-0 - Modification of Ti surfaces by Langmuir-Blodgett hybrid films containing biominerals and strontium ranelate to promote the controled Sr2+ release |
| Grantee: | Marcos Antonio Eufrásio Cruz |
| Support Opportunities: | Scholarships in Brazil - Master |