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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis of Sr-morin complex and its in vitro response: decrease in osteoclast differentiation while sustaining osteoblast mineralization ability

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Cruz, Marcos A. E. [1] ; Tovani, Camila B. [1] ; Favarin, Bruno Z. [1] ; Soares, Mariana P. R. [2] ; Fukada, Sandra Y. [2] ; Ciancaglini, Pietro [1] ; Ramos, Ana P. [1]
Total Authors: 7
[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF MATERIALS CHEMISTRY B; v. 7, n. 5, p. 823-829, FEB 7 2019.
Web of Science Citations: 2

Strontium ranelate (SrR) has been used as the ultimate choice for osteoporosis treatment. However, the development of more tolerable and bioactive Sr2+ carriers is still a need. The design of Sr2+-based platforms has moved towards the obtention of anion carriers that can also exhibit a positive effect on bone metabolism. In this sense, we used morin, a natural flavonoid, as a new arrangement for Sr2+ carriage in the synthesis of an Sr2+ complex. It has been claimed that phenolic compounds promote bone health. Therefore, we hypothesized that the association of Sr2+ with morin could improve its anabolic effects. Complexes with the general formula {[}(C15H9O7)Sr(H2O)(2)]Cl center dot 3H(2)O were synthesized and characterized by elemental analysis, thermogravimetry, UV-Vis and infrared absorption spectroscopies and H-1-nuclear magnetic resonance. We showed that the complexation between morin and Sr2+ occurred among the 3-OH and 4C=O groups of morin. Preosteoclasts cultures with the Sr-morin complex exhibited a reduced osteoclast differentiation rate and sustained osteoblast mineralization ability. The response of Sr-morin was higher than that observed for SrR at the same concentration range. Considering the above-mentioned observations, the Sr-morin complex could be an interesting approach to be further exploited not only as an alternative treatment for osteoporosis but also in the design of materials for faster osteointegration. (AU)

FAPESP's process: 17/08892-9 - Bioactive surfaces designed from Langmuir-Blodgett Films and Biominerals
Grantee:Ana Paula Ramos
Support type: Regular Research Grants
FAPESP's process: 15/08774-0 - Modification of Ti surfaces by Langmuir-Blodgett hybrid films containing biominerals and strontium ranelate to promote the controled Sr2+ release
Grantee:Marcos Antonio Eufrásio Cruz
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/24249-0 - Association of osteogenic proteins in biominerals and metallic oxides doped with rare-earth: interaction with membrane models systems
Grantee:Camila Bussola Tovani
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/09034-0 - The role of O-glycosylation on the modulation of osteoclastogenesis and bone resorption
Grantee:Sandra Yasuyo Fukada Alves
Support type: Regular Research Grants
FAPESP's process: 16/21236-0 - Extracellular matrix vesicles (MVs) mimetic systems to study the regulation of the biomineralization process: proteoliposomes containing NPP1 and Annexin V
Grantee:Pietro Ciancaglini
Support type: Regular Research Grants