Size Control of Carbon Spherical Shells for Sensitive Detection of Paracetamol in Sweat, Saliva, and Urine

Author(s)

Campos, Anderson M. ^[1] ; Raymundo-Pereira, Paulo A. ^[2] ; Mendonca, Camila D. ^[1] ; Calegaro, Marcelo L. ^[1] ; Machado, Sergio A. S. ^[1] ; Oliveira, Jr., Osvaldo N. ^[2]

Affiliation

^[1] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13566590 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil

• Document type: Journal article
• Source: ACS APPLIED NANO MATERIALS; v. 1, n. 2, p. 654-661, FEB 2018.
• Web of Science Citations: 9

Abstract

We report on a facile strategy for separating carbon spherical shells (CSS) using centrifugation, with which shells were produced with diameter varying from 400 to 500 nm according to scanning and transmission electron microscopies. The shells were made of 79% carbon and 21% oxygen, and their surface was functionalized with carbonyl and hydroxyl groups. The CSS could form a homogeneous film on a glassy carbon (GC) electrode surface and be used in a sensing platform. In electroanalytical experiments, the sensitivity of the GC/CSS electrode for paracetamol increased with decreasing size of CSS. For 400 nm CSS, the sensitivity was 0.02 mu A mu mol(-1) L, and the limit of detection and quantification in sweat, saliva, and urine samples was 120 and 400, 286 and 470, and 584 and 530 nmol L-1, respectively, which represents the highest performance among carbon-based sensors found in the literature. The GC/CSS electrodes were stable, robust against typical interferents, and allowed detection of paracetamol in sweat, saliva, and urine samples with a performance indistinguishable from conventional high-performance liquid chromatography. (AU)

• FAPESP's process: 16/01919-6 - Design and fabrication of nanostructured flexible devices for biomarkers detection
• Grantee: Paulo Augusto Raymundo Pereira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/05197-0 - Development of electrochemical sensors based in mesoporous sílica containing graphene for analysis of bisphenol A
• Grantee: Anderson Massahiro de Campos
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/14262-7 - Nanostructured films from biologically-relevant materials
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/12759-0 - Development of an advanced electroanalytical methodology for quantification of the hormones 17²-estradiol and 17±-etinilestradiol in supply water samples using electrodes modified with graphene, gold nanoparticles and quantum dots
• Grantee: Sergio Antonio Spinola Machado
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/17689-9 - Preparation and characterization of bifunctional-nanostructured surfaces of Au-Pt obtained via templates for application in sensors and biosensors
• Grantee: Paulo Augusto Raymundo Pereira
• Support Opportunities: Scholarships in Brazil - Doctorate