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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epstein-Barr Virus-Positive Mucocutaneous Ulcer Mimicking Peri-Implantitis in a Patient With Systemic Lupus Erythematosus

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Takahama Jr, Ademar ; de Lima, Heliton Gustavo [1] ; Ito, Fabio Augusto [1] ; Ribeiro-Silva, Alfredo [2] ; Leon, Jorge Esquiche [3]
Total Authors: 5
[1] Takahama Jr, Jr., Ademar, Univ Estadual Londrina, Dept Oral Med & Pediat Dent, Londrina - Brazil
[2] Univ Sao Paulo, Dept Pathol & Forens Med, Ribeirao Preto Med Sch, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Dept Stomatol Publ Oral Hlth & Forens Dent, Sch Dent Ribeirao Preto, Pathol, Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY; v. 77, n. 5, p. 977-984, MAY 2019.
Web of Science Citations: 0

Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is characterized by cutaneous and/or mucosal ulcers in patients receiving immunosuppressive medication or with age-related immunosenescence. Its microscopic appearance often leads to a diagnostic challenge, sometimes mimicking an overt lymphoma. A 47-year-old woman, with a previous diagnosis of systemic lupus erythematosus, was referred for evaluation of a gingival ulcer, present for about 2 months and located in the maxillary peri-implant mucosa around implants, resembling peri-implantitis. An incisional biopsy was performed, and the microscopic evaluation showed a polymorphic infiltrate with some Reed-Sternberg-like cells. Immunohistochemistry showed positive findings for CD20, CD30, CD45, PAX-5, MUM-1, LMP-1 and EBER1/2, establishing the diagnosis of EBVMCU. After 2 months, total regression of the lesion was noted without any intervention. We discuss the possible association between the EBVMCU and systemic lupus erythematosus; to our knowledge, this is the first report of an EBVMCU simulating peri-implantitis. (C) 2019 American Association of Oral and Maxillofacial Surgeons (AU)

FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region
Grantee:Jorge Esquiche León
Support type: Regular Research Grants
FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in Acute Promyelocytic Leukemia: in vitro, ex vivo and murine experimental model studies
Grantee:Luciana Yamamoto de Almeida
Support type: Scholarships in Brazil - Post-Doctorate