Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome

Author(s)

Dantas, Wagner Silva ^[1] ; das Neves, Willian ^[2] ; Gil, Saulo ^[1] ; Grimaldi Barcellos, Cristiano Roberto ^[3] ; Rocha, Michele Patrocinio ^[4] ; de Sa-Pinto, Ana Lucia ^[5] ; Roschel, Hamilton ^{[5, 1]} ; Gualano, Bruno ^{[5, 1]}

Affiliation

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Sch Phys Educ & Sport, Sch Med, Sao Paulo - Brazil

^[2] Inst Canc Estado Sao Paulo, Clin Oncol Serv, Sao Paulo - Brazil

^[3] Pontificia Univ Catolica Sao Paulo, Endocrinol Serv, Sao Paulo - Brazil

^[4] Hosp Santa Marcelina, Dept Endocrinol, Fac Med Santa Marcelina, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Div Rheumatol, Hosp Clin HCFMUSP, Fac Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: CYTOKINE; v. 120, p. 66-70, AUG 2019.
• Web of Science Citations: 0

Abstract

Polycystic ovary syndrome (PCOS) is characterized by exacerbated inflammation, which is implicated in cardiometabolic dysfunction. This study aimed to examine the potential effects of acute exercise on inflammatory responses in obese/overweight PCOS women and their controls. Participants underwent a single bout of moderate-intensity aerobic exercise (30 min at similar to 65% of VO2peak). Blood and muscle samples were collected immediately before (PRE) and 60 min after the exercise session. Cytokines (i.e., IL-1 beta, IL-6, IL-4, IL-10, TNF-alpha) were measured both in plasma and in skeletal muscle, and proteins related to inflammatory signaling (IKK alpha/beta and JNK) were assessed in skeletal muscle. At PRE, PCOS showed elevated muscle TNF-alpha (+62%, p = 0.0012) and plasma IL-1 beta (+76%, p = 0.0010) compared to controls. In PCOS, exercise decreased plasma and muscle TNF-alpha (-14%, p = 0.0003 and -46%, p = 0.0003), as well as increased plasma and muscle IL-4 (+147%, p = 0.0018 and +62%, p = 0.0474) and plasma IL-10 (+38%, p = 0.0029). Additionally, IKK alpha/beta and JNK phosphorylation in skeletal muscle, which was higher in PCOS at PRE, was significantly reduced by exercise (-58%, p < 0.0001 and -46%, p < 0.0001, respectively), approaching control levels. Person's correlations between PRE values and delta changes (i.e., exercise effect) showed significant, negative associations for plasma IL-1 beta (r = -0.92, p < 0.0001), TNF-alpha (r = -0.72, p = 0.0100) and IL-6 (r = -0.58, p = 0.05), and muscle INF-alpha (r = -0.95, p < 0.0001), IKK alpha/beta (r = -0.75, p = 0.005), and JNK (r = -0.94, p < 0.0001) in PCOS. In conclusion, exercise can mitigate the inflammatory milieu in women with PCOS. The anti-inflammatory role of exercise could underlie its cardiometabolic protection in PCOS. (AU)

• FAPESP's process: 12/14650-4 - Acute effect of exercise on molecular pathways related to skeletal muscle glucose uptake in patients with polycystic ovary syndrome
• Grantee: Bruno Gualano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/04744-4 - Effects of strength training on skeletal muscle in mice with cachexia induced cancer.
• Grantee: Willian das Neves Silva
• Support Opportunities: Scholarships in Brazil - Master