| Full text | |
| Author(s): |
Nascimento, T. L.
[1]
;
Conte, T. C.
[1]
;
Rissato, T. S.
[1]
;
Luna, M. S.
[2]
;
Soares, A. G.
[3]
;
Moriscot, A. S.
[1]
;
Yamanouye, N.
[2]
;
Miyabara, E. H.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Biomed Sci Inst, Dept Anat, Av Lineu Prestes 2415, BR-05508000 Sao Paulo, SP - Brazil
[2] Butantan Inst, Pharmacol Lab, Av Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Biomed Sci Inst, Dept Pharmacol, Av Lineu Prestes 1524, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Toxicon; v. 167, p. 6-9, SEP 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
This study evaluated cellular and molecular effects of radicicol, a heat shock protein (HSP) inducer, on the regeneration of skeletal muscle injured by crotoxin, the main toxin isolated from Crotalus durissus terrificus venom. Regenerating muscles treated with radicicol had decreased NF-kB activation. Differentiating myoblasts treated with radicicol showed reduced number of NF-kB positive nuclei and increased fusion index. The results suggest that radicicol enhances regeneration of muscle by attenuating NF-kB activation and increasing myogenic differentiation. (AU) | |
| FAPESP's process: | 13/04783-0 - The influence of heat shock proteins in the recovery of skeletal muscle of old mice |
| Grantee: | Tábata Leal Nascimento |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/21238-2 - Skeletal muscle plasticity after injury: role of beta2-adrenoceptor |
| Grantee: | Elen Haruka Miyabara |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/53528-7 - Skeletal muscle plasticity after injury and atrophy: influence of heat shock proteins |
| Grantee: | Elen Haruka Miyabara |
| Support Opportunities: | Regular Research Grants |