Primary aromatic amines in kitchenware: Determination by liquid chromatography-tandem mass spectrometry

Author(s)

Favaro Perez, Mary Angela ^{[1, 2]} ; Padula, Marisa ^[2] ; Moitinho, Daisy ^[2] ; Grespan Bottoli, Carla Beatriz ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Campinas, SP - Brazil

^[2] Packaging Technol Ctr CETEA, Inst Food Technol ITAL, Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Chromatography A; v. 1602, p. 217-227, SEP 27 2019.
• Web of Science Citations: 2

Abstract

The aim of this paper is to develop and validate a methodology with potential for routine analysis that allows a fast and easy quantification of 19 primary aromatic amines (PAAs) in acid simulant (3% (w/v) acetic acid aqueous) in food contact materials (FCM). The main reason for studying these amines was the fact that some of them have a carcinogenic factor according to toxicological studies. To validate the method, the parameters linearity, limit of detection (LOD) and limit of quantification (LOO), precision and accuracy using an UPLC-MS/MS were evaluated. This study also analyzed 36 samples of kitchenware obtained from retail markets: 16 were made of polyamide (PA), one was made of polypropylene (PP) and 19 were made of silicone. The origins of samples were Brazil, China and Turkey. Eleven samples had levels of 4,4'-cliaminodiphenylmethane higher than permitted by legislation and five samples showed values of aniline above the limit. Considering the Mood test for polyamides, there were significant differences between the samples from Brazil and China, as well as between the colors in the silicone samples. Regarding the polyamides, the Chinese samples showed higher amounts of PAAs than the Brazilian ones, being above that allowed by legislation. Three Chinese silicone samples presented values above the legislation limit. These were all from the same importer. (C) 2019 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 18/07234-0 - 47th International Symposium on High Perfomance Liquid Phase Separations and Related Techniques
• Grantee: Carla Beatriz Grespan Bottoli
• Support Opportunities: Research Grants - Meeting - Abroad
• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/26300-6 - Assessment of potential food contamination by primary aromatic amines (PAAs) with focus on kitchenware
• Grantee: Marisa Padula
• Support Opportunities: Regular Research Grants