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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats

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Gabriel Mulinari-Santos ; Jaqueline Silva dos Santos ; Letícia Pitol Palin ; Ana Cláudia Ervolino da Silva ; Cristina Antoniali ; Leonardo Perez Faverani ; Roberta Okamoto
Total Authors: 7
Document type: Journal article
Source: Journal of Applied Oral Science; v. 27, p. -, 2019.
Web of Science Citations: 0

Abstract Hypertension is one of the main causes of premature death in the world; also, it is associated with several bone alterations. Preclinical studies have demonstrated delayed alveolar bone healing in hypertensive rats. However, losartan has been favorable for consolidation of bone grafts and reduction in active periodontitis. Therefore, losartan is suggested to be effective in bone formation stages, as well as in the synthesis of matrix proteins and mineralization. Objectives: To evaluate the alveolar bone dynamics in hypertensive rats treated with losartan by laser confocal microscopy and histological analysis. Methodology: Thirty-two rats, 16 spontaneously hypertensive rats (SHR) and 16 Wistar albinus rats, treated or not with losartan (30 mg/kg/day) were used. Calcein fluorochrome at 21 days and alizarin red fluorochrome at 49 days were injected in rats (both 20 mg/kg). The animals were submitted to euthanasia 67 days after treatment, and then the right maxilla was removed for laser confocal microscopy analysis and the left maxilla for histological analysis. Results: This study showed a greater calcium marking in normotensive animals treated with losartan in relation to the other groups. Laser confocal microscopy parameters showed higher values of bone volume formed, mineralized surface, active surface of mineralization and bone formation rate in normotensive animals treated with losartan. However, a smaller mineralized surface was observed in all hypertensive animals. Conclusion: Losartan can improve bone mineralization parameters under normal physiological conditions, but the same anabolic effect does not occur under hypertension. (AU)

FAPESP's process: 16/03245-2 - Peri-implant bone healing in the tibia of spontaneously hypertensive rats (SHR) treated with losartan: a biomechanical, molecular, microtomography, bone dynamics by fluorochromes, immunohistochemical and histological analysis
Grantee:Gabriel Mulinari dos Santos
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/23082-3 - Characterization of peri-implant bone tissue in hypertensive and estrogen-deficient rats after the synergistic action of losartan and alendronate sodium
Grantee:Gabriel Mulinari dos Santos
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/16912-0 - Performance evaluation of two different surface texturing in the peri-implant osteogenesis in spontaneously hypertensive rats (SHR) and treated with losartan
Grantee:Jaqueline Silva dos Santos
Support type: Scholarships in Brazil - Scientific Initiation