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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrochemical degradation of the antibiotic ciprofloxacin in a flow reactor using distinct BDD anodes: Reaction kinetics, identification and toxicity of the degradation products

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Author(s):
Wachter, Naihara [1] ; Aquino, Jose Mario [1] ; Denadai, Marina [1] ; Barreiro, Juliana C. [2] ; Silva, Adilson Jose [3] ; Cass, Quezia B. [1] ; Bocchi, Nerilso [1] ; Rocha-Filho, Romeu C. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, CP 676, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Quim Sao Carlos, Ave Joao Dagnone 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Engn Quim, CP 676, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Chemosphere; v. 234, p. 461-470, NOV 2019.
Web of Science Citations: 0
Abstract

The performances of distinct BDD anodes (boron doping of 100, 500 and 2500 ppm, with sp(3)/sp(2) carbon ratios of 215, 325, and 284, respectively) in the electrochemical degradation of ciprofloxacin - CIP (0.5 L of 50 mg L-1 in 0.10 M Na2SO4, at 25 degrees C) were comparatively assessed using a recirculating flow system with a filter-press reactor. Performance was assessed by monitoring the CIP and total organic carbon (TOC) concentrations, oxidation intermediates, and antimicrobial activity against Escherichia coli as a function of electrolysis time. CIP removal was strongly affected by the solution pH (kept fixed), flow conditions, and current density; similar trends were obtained independently of the BDD anode used, but the BDD100 anode yielded the best results. Enhanced mass transport was achieved at a low flow rate by promoting the solution turbulence within the reactor. The fastest complete CIP removal (within 20 min) was attained at j = 30 mA cm(-2), pH = 10.0, and q(v)= 2.5 L min(-1) + bypass turbulence promotion. TOC removal was practically accomplished only after 10 h of electrolysis, with quite similar performances by the distinct BDD anodes. Five initial oxidation intermediates were identified (263 <= m/z <= 348), whereas only two terminal oxidation intermediates were detected (oxamic and formic acids). The antimicrobial activity of the electrolyzed CIP solution was almost completely removed within 10 h of electrolysis. The characteristics of the BDD anodes only had a marked effect on the CIP removal rate (best performance by the least-doped anode), contrasting with other data in the literature. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/54040-8 - Acquisition of a high-resolution Orbitrap mass spectrometer for the discovery and structural analysis of biologically active compounds: applications in proteomics, biomarkers, synthesis, isolation, and characterization of natural products, studies of redox systems in food and enzymatic synthesis
Grantee:Emanuel Carrilho
Support type: Multi-user Equipment Program
FAPESP's process: 09/17138-0 - Methods for quantification of small molecules in biological fluids: the use of restricted access media columns for direct injection of samples
Grantee:Quezia Bezerra Cass
Support type: Regular Research Grants
FAPESP's process: 12/13002-9 - Electrochemical degradation of a pharmaceutical: comparison between anodes
Grantee:Naihara Wachter
Support type: Scholarships in Brazil - Master