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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of serotonin by using a thin film containing graphite, nanodiamonds and gold nanoparticles anchored in casein

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Vidal Ramos, Matheus Mesquita [1] ; Carvalho, Jefferson H. S. [1] ; de Oliveira, Paulo Roberto [2] ; Janegitz, Bruno Campos [1]
Total Authors: 4
[1] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil
[2] Fed Univ Parana UFPR, Dept Chem, BR-81531980 Curitiba, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MEASUREMENT; v. 149, JAN 2020.
Web of Science Citations: 0

The determination of serotonin has become relevant in biological fluid analysis since some neurological disorders may be related to abnormal amounts of this neurotransmitter in human beings. In this work, it is proposed the construction of a low-cost electrode sensitive to the quantification of serotonin by a bio-film of graphite, nanodiamonds and gold nanoparticles anchored in casein. The casein biofilm was used to anchor the conductive nanomaterials on the GCE. Measurements were performed by differential pulse voltammetry in which showed a linear response with LDR of 0.3 to 3.0 mu mol L-1, LOD of 0.1 mu mol L-1 and a sensitivity of 0.18 mu A L mol(-1). The sensor was applied for the serotonin quantification in synthetic urine samples enriched with good recovery (91.4 to 103%). Therefore, the proposed electrode improved the conductivity and the electronic transfer capacity of the pristine electrode by low-cost biofilm, which could be applied in electrochemical biosensing. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 17/21898-6 - New conductive devices for application in electrochemical sensing and biosensing
Grantee:Bruno Campos Janegitz
Support type: Regular Research Grants
FAPESP's process: 19/01844-4 - Development of nanostructured electrodes for determination of agrotoxic residues in honey
Grantee:Paulo Roberto de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/21097-3 - Bee-agriculture interactions: perspectives to sustainable use
Grantee:Osmar Malaspina
Support type: Research Projects - Thematic Grants