Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters

Author(s)

Maximo Daneluti, Andre Luis ^[1] ; Neto, Francisco Mariano ^[2] ; Ruscinc, Nadia ^[1] ; Lopes, Ingrid ^[1] ; Robles Velasco, Maria Valeria ^[1] ; Matos, Jivaldo Do Rosario ^[3] ; Baby, Andre Rolim ^[1] ; Kalia, Yogeshvar N. ^{[4, 5]}

Affiliation

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Phys, BR-05508090 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Sao Paulo - Brazil

^[4] Univ Geneva, Sch Pharmaceut Sci, 1 Rue Michel Servet, CH-1211 Geneva - Switzerland

^[5] Univ Lausanne, 1 Rue Michel Servet, CH-1211 Geneva - Switzerland

• Document type: Journal article
• Source: International Journal of Pharmaceutics; v. 570, OCT 30 2019.
• Web of Science Citations: 0

Abstract

Avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC), are widely used UV filters. The aim of this study was to investigate the effect of incorporation in mesoporous silica (SBA-15) on their cutaneous deposition and permeation. Stick formulations containing ``free{''} and ``incorporated{''} UV filters (SF1 and SF2, respectively) were prepared and characterized with respect to their physicochemical, thermal, and functional properties. Cutaneous delivery experiments using porcine skin with quantification by UHPLC-MS/MS, demonstrated that skin deposition of AVO and OXY after application of SF2 for 6 and 12 h was significantly lower than that from SF1 at each time-point (Student t-test, p < 0.05): e.g. OXY permeation across the skin was 30-, 12- and 1.5-fold lower after 6, 12 and 24 h, respectively, following application of SF2. Cutaneous biodistribution profiles of AVO and OXY to 800 mu m evidenced a significant decrease in the amounts in the viable epidermis and dermis. In contrast, deposition of the more lipophilic OMC was not significantly different (p > 0.05). In vitro photoprotective efficacy results demonstrated that adsorption/entrapment of UV filters enhanced the sun protection factor by 94%. In conclusion, SBA-15, an innovative mesoporous material, increased photoprotection by UV filters while reducing their cutaneous penetration and transdermal permeation. (AU)

• FAPESP's process: 13/18689-5 - Influence of actives / bioactive compounds on physicochemical and in vitro and in vivo functional parameters of lip molded sunscreens
• Grantee: André Rolim Baby
• Support Opportunities: Regular Research Grants