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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biosensing of D-dimer, making the transition from the central hospital laboratory to bedside determination

Full text
Author(s):
Tasic, Nikola [1] ; Paixao, Thiago R. L. C. [1] ; Goncalves, Luis Moreira [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Ave Prof Lineu Prestes 748, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Talanta; v. 207, JAN 15 2020.
Web of Science Citations: 0
Abstract

Since the disclosure of the fibrinogen degradation mechanism, around half a century ago, a significant number of papers have been published related to the clinical relevance of D-dimer, a molecule immune to additional enzymatic decomposition by plasmin. Due to the obliquity of regulating blood coagulation in pathological events, the number of diseases and conditions associated with abnormal levels of D-dimer includes deep vein thrombosis, pulmonary embolism, sepsis, myocardial infarction, disseminated intravascular coagulation, among many others. D-dimer not only is an important player in medical diagnosis but also its role as a prognosis biomarker is being revealed. However, the number of analytical alternative methods has not accompanied this trend, even though novel simple point-of-care devices would certainly boost the relevance of D-dimer in emergency medicine. Some reasons for that could be related to the fact that D-dimer is a challenging analyte present in complex samples like blood. In this manuscript, subsequent to a fibrinogen degradation process introduction, it is provided a historical overview of the early D-dimer assays, followed by an extended focus on innovative solutions, with a spotlight on the electrochemical bioanalytical devices. The discussion is accompanied with a critical analysis and concluding thoughts concerning future perspectives. (AU)

FAPESP's process: 17/10522-5 - Development of alternative methods for fabrication of electrochemical paper-based sensors
Grantee:Thiago Regis Longo Cesar da Paixão
Support Opportunities: Regular Research Grants
FAPESP's process: 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications
Grantee:Mauro Bertotti
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/13922-7 - Development of a point-of-care biosensor for the swift determination of D-Dimers
Grantee:Nikola Tasic
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/14425-7 - A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs)
Grantee:Luís Francisco Moreira Gonçalves
Support Opportunities: Research Grants - Young Investigators Grants