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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study

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Author(s):
Teixeira, Lucas R. [1] ; Almeida, Luciana Y. [2] ; Silva, Rodrigo N. [3] ; Mesquita, Ana T. M. [4] ; Colturato, Carla B. N. [1] ; Silveira, Heitor A. [3] ; Duarte, Andressa [1] ; Ribeiro-Silva, Alfredo [1] ; Leon, Jorge E. [3]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP, Dept Pathol & Forens Med, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP, Dept Clin Med, Hematol Div, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ave Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil
[4] Fed Univ Jequitinhonha & Mucuri Valleys, Dept Dent Clin Stomatol, Diamantina, MG - Brazil
Total Affiliations: 4
Document type: Journal article
Source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 41, n. 12, p. 4111-4120, DEC 2019.
Web of Science Citations: 0
Abstract

Background M2 macrophages are often detected in oral squamous cell carcinoma (OSCC), which, influenced by hypoxic conditions, appear to have high angiogenesis-inducing capacity. However, the effects of immunosenescence on tumor-associated macrophages (TAMs) and angiogenesis in OSCC are unknown. Methods Fifty-seven OSCCs were divided into 3 groups (I: 65 years {[}n = 20]). Immunohistochemistry for CD68 and CD163 (TAMs), and CD34 and D2-40 for microvessel density (MVD), microvessel area (MVA), and total vascular area (TVA) were performed. Results All groups showed similar clinicopathological and immunohistochemical findings. Similar CD68 and CD163 expression, confirmed a M2 phenotype. MVD, MVA, and TVA were similar, however, with significant predominance of blood vessels. No significant correlation between macrophage and angiogenic markers was observed. Conclusions A similar TAM and angiogenesis profile suggests the participation of other mechanisms, instead immunosenescence, in young and elderly OSCC patients. (AU)

FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
Grantee:Heitor Albergoni da Silveira
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region
Grantee:Jorge Esquiche León
Support type: Regular Research Grants
FAPESP's process: 17/02502-4 - M1 and M2 macrophages and its relation with angiogenesis in oral squamous cell carcinomas affecting young and elderly patients
Grantee:Lucas Ribeiro Teixeira
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies.
Grantee:Luciana Yamamoto de Almeida
Support type: Scholarships in Brazil - Post-Doctorate