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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of age and gender on sex steroid receptors in rat masticatory muscles

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Author(s):
Mantelli Galhardo, Alessandra Pucci [1] ; Mukai, Marcio Katsuyoshi ; Mori, Matsuyoshi [2] ; Carvalho, Katia Candido [1, 2] ; Pinheiro Baracat, Maria Candida [1] ; Simoes, Manuel de Jesus [3] ; Soares, Jr., Jose Maria [1] ; Baracat, Edmund Chada [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Obstet & Ginecol, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Odontol, Dept Protese, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Morfol & Genet, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, DEC 5 2019.
Web of Science Citations: 0
Abstract

The temporomandibular muscle dysfunction is characterized by myofascial pain and is more prevalent in women of reproductive age. Sex steroid hormones are hypothetically involved in the dysfunction, but few are the studies of steroid receptors in masticatory and mastication-related muscles. Our aim was to determine estrogen and testosterone receptor expression in rat masticatory and mastication-related muscles within the context of age and gender. Twelve rats were equally divided into four groups: (a) 10-month-old females; (b) 10-month-old males; (c) 24-month-old females; and (d) 24-month-old males. Euthanasia of the females was performed in the proestrous phase (vaginal smears) and the masticatory and accessory muscles were removed for immunohistochemical analysis. Statistical analysis was performed with ANOVA and the Tukey test. Estrogen receptor expression was similarly low in all muscles and groups. Testosterone receptor expression in the Masseter muscle of the 24-month-old male rats was higher than that in the other groups and significantly superior to its expression in the Posterior Digastric muscle. In short, testosterone receptor expression was highest in old male rats. If we generalize to humans, this fact could indicate age- and sex-related hormonal influence on temporomandibular muscle dysfunction. Further studies, however, are necessary to strengthen this hypothesis. (AU)

FAPESP's process: 14/00126-7 - Presence, location and expression of sex steroid receptors in the temporomandibular joints of rats
Grantee:Alessandra Pucci Mantelli Galhardo
Support type: Scholarships in Brazil - Post-Doctorate